| http://purl.uniprot.org/citations/27101095 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27101095 | http://www.w3.org/2000/01/rdf-schema#comment | "Primary aldosteronism (PA) is one of the most frequent forms of secondary hypertension, associated with atherosclerosis and higher risk of cardiovascular events. Platelets play a key role in the atherosclerotic process. The aim of the study was to evaluate the platelet activation by measuring serum levels of soluble CD40L (sCD40L) and P-selectin (sP-selectin) in consecutive PA patients [subgroup: aldosterone-secreting adrenal adenoma (APA) and bilateral adrenal hyperplasia (IHA)], matched with essential hypertensive (EH) patients. The subgroup of APA patients was revaluated 6-months after unilateral adrenalectomy. In all PA group, we measured higher serum levels of both sP-selectin (14.29±9.33 pg/ml) and sCD40L (9.53±4.2 ng/ml) compared to EH patients (9.39±5.3 pg/ml and 3.54±0.94 ng/ml, respectively; p<0.001). After removal of APA, PA patients showed significant reduction of blood pressure (BP) values, plasma aldosterone (PAC) levels and ARR-ratio, associated with a significant reduction of sP-selectin (16.74±8.9 pg/ml vs. 8.1±3.8 pg/ml; p<0.01) and sCD40L (8.6±1 ng/ml vs. 5.24±0.94 ng/ml; p<0.001). In PA patients, we found a significant correlation between sP-selectin and sCD40L with PAC (r=0.52, p<0.01; r=0.50, p<0.01, respectively); this correlation was stronger in APA patients (r=0.54; p<0.01 r=0.63; p<0.01, respectively). Our results showed that PA is related to platelet activation, expressed as higher plasma values of sCD40L and sP-selectin values. Surgical treatment and consequent normalization of aldosterone secretion was associated with significant reduction of sCD40L and sP-selectin values in APA patients."xsd:string |
| http://purl.uniprot.org/citations/27101095 | http://purl.org/dc/terms/identifier | "doi:10.1055/s-0042-103588"xsd:string |
| http://purl.uniprot.org/citations/27101095 | http://purl.uniprot.org/core/author | "De Toma G."xsd:string |
| http://purl.uniprot.org/citations/27101095 | http://purl.uniprot.org/core/author | "Letizia C."xsd:string |
| http://purl.uniprot.org/citations/27101095 | http://purl.uniprot.org/core/author | "Zinnamosca L."xsd:string |
| http://purl.uniprot.org/citations/27101095 | http://purl.uniprot.org/core/author | "Iannucci G."xsd:string |
| http://purl.uniprot.org/citations/27101095 | http://purl.uniprot.org/core/author | "Pignatelli P."xsd:string |
| http://purl.uniprot.org/citations/27101095 | http://purl.uniprot.org/core/author | "Violi F."xsd:string |
| http://purl.uniprot.org/citations/27101095 | http://purl.uniprot.org/core/author | "Iacobellis G."xsd:string |
| http://purl.uniprot.org/citations/27101095 | http://purl.uniprot.org/core/author | "Petramala L."xsd:string |
| http://purl.uniprot.org/citations/27101095 | http://purl.uniprot.org/core/author | "Carnevale R."xsd:string |
| http://purl.uniprot.org/citations/27101095 | http://purl.uniprot.org/core/author | "Marinelli C."xsd:string |
| http://purl.uniprot.org/citations/27101095 | http://purl.uniprot.org/core/author | "Galassi M."xsd:string |
| http://purl.uniprot.org/citations/27101095 | http://purl.uniprot.org/core/author | "Ciardi A."xsd:string |
| http://purl.uniprot.org/citations/27101095 | http://purl.uniprot.org/core/author | "Lucia P."xsd:string |
| http://purl.uniprot.org/citations/27101095 | http://purl.uniprot.org/core/author | "Concistre A."xsd:string |
| http://purl.uniprot.org/citations/27101095 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27101095 | http://purl.uniprot.org/core/name | "Horm Metab Res"xsd:string |
| http://purl.uniprot.org/citations/27101095 | http://purl.uniprot.org/core/pages | "440-445"xsd:string |
| http://purl.uniprot.org/citations/27101095 | http://purl.uniprot.org/core/title | "Enhanced Soluble Serum CD40L and Serum P-Selectin Levels in Primary Aldosteronism."xsd:string |
| http://purl.uniprot.org/citations/27101095 | http://purl.uniprot.org/core/volume | "48"xsd:string |
| http://purl.uniprot.org/citations/27101095 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27101095 |
| http://purl.uniprot.org/citations/27101095 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27101095 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z509-mappedCitation-27101095 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27101095 |