| http://purl.uniprot.org/citations/27101932 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27101932 | http://www.w3.org/2000/01/rdf-schema#comment | "Smooth muscle sphincters exhibit basal tone and control passage of contents through organs such as the gastrointestinal tract; loss of this tone leads to disorders such as faecal incontinence. However, the molecular mechanisms underlying this tone remain unknown. Here, we show that deletion of myosin light-chain kinases (MLCK) in the smooth muscle cells from internal anal sphincter (IAS-SMCs) abolishes basal tone, impairing defecation. Pharmacological regulation of ryanodine receptors (RyRs), L-type voltage-dependent Ca(2+) channels (VDCCs) or TMEM16A Ca(2+)-activated Cl(-) channels significantly changes global cytosolic Ca(2+) concentration ([Ca(2+)]i) and the tone. TMEM16A deletion in IAS-SMCs abolishes the effects of modulators for TMEM16A or VDCCs on a RyR-mediated rise in global [Ca(2+)]i and impairs the tone and defecation. Hence, MLCK activation in IAS-SMCs caused by a global rise in [Ca(2+)]i via a RyR-TMEM16A-VDCC signalling module sets the basal tone. Targeting this module may lead to new treatments for diseases like faecal incontinence."xsd:string |
| http://purl.uniprot.org/citations/27101932 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms11358"xsd:string |
| http://purl.uniprot.org/citations/27101932 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/27101932 | http://purl.uniprot.org/core/author | "Chen C."xsd:string |
| http://purl.uniprot.org/citations/27101932 | http://purl.uniprot.org/core/author | "Sun J."xsd:string |
| http://purl.uniprot.org/citations/27101932 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/27101932 | http://purl.uniprot.org/core/author | "Zhao W."xsd:string |
| http://purl.uniprot.org/citations/27101932 | http://purl.uniprot.org/core/author | "Zheng K."xsd:string |
| http://purl.uniprot.org/citations/27101932 | http://purl.uniprot.org/core/author | "Lu P."xsd:string |
| http://purl.uniprot.org/citations/27101932 | http://purl.uniprot.org/core/author | "Tao T."xsd:string |
| http://purl.uniprot.org/citations/27101932 | http://purl.uniprot.org/core/author | "Zhang C.H."xsd:string |
| http://purl.uniprot.org/citations/27101932 | http://purl.uniprot.org/core/author | "Chen C.P."xsd:string |
| http://purl.uniprot.org/citations/27101932 | http://purl.uniprot.org/core/author | "Peng Y.J."xsd:string |
| http://purl.uniprot.org/citations/27101932 | http://purl.uniprot.org/core/author | "Zhu M.S."xsd:string |
| http://purl.uniprot.org/citations/27101932 | http://purl.uniprot.org/core/author | "Lifshitz L.M."xsd:string |
| http://purl.uniprot.org/citations/27101932 | http://purl.uniprot.org/core/author | "Keaney J.F. Jr."xsd:string |
| http://purl.uniprot.org/citations/27101932 | http://purl.uniprot.org/core/author | "Fogarty K.E."xsd:string |
| http://purl.uniprot.org/citations/27101932 | http://purl.uniprot.org/core/author | "He W.Q."xsd:string |
| http://purl.uniprot.org/citations/27101932 | http://purl.uniprot.org/core/author | "Liu D.H."xsd:string |
| http://purl.uniprot.org/citations/27101932 | http://purl.uniprot.org/core/author | "Qiao Y.N."xsd:string |
| http://purl.uniprot.org/citations/27101932 | http://purl.uniprot.org/core/author | "Craige S.M."xsd:string |
| http://purl.uniprot.org/citations/27101932 | http://purl.uniprot.org/core/author | "ZhuGe R."xsd:string |
| http://purl.uniprot.org/citations/27101932 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27101932 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |