| http://purl.uniprot.org/citations/27104500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27104500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27104500 | http://www.w3.org/2000/01/rdf-schema#comment | "Mastoparans from the venom of social wasps have attracted considerable attention as effective antibiotic candidates. In this study, mastoparan V1 (MP-V1) from Vespula vulgaris was first disclosed to have a peptide amino acid sequence distinct from typical mastoparans and its biochemical properties and antimicrobial effects were compared with those of typical mastoparans MP-L, -X(V) and -B. Circular dichroism (CD) spectroscopy revealed that MP-V1 and -X(V) form more stable α-helical conformations in lipid membrane-like environments than MP-L and -B. In parallel, these two also showed more effective antimicrobial activities against the pathogens than did MP-L and -B. Although MP-V1 had a less stable α-helical conformation than MP-X(V), it showed stronger antimicrobial effects against Streptococcus mutans and Salmonella enterica than MP-X(V). In the meantime, analysis of hemolytic activity revealed a range of doses (~50 μM) that exhibited little potent cytotoxicity on human erythrocytes. Finally, the atypical MP-V1 peptide amino acid sequence provided important clues to understanding its antimicrobial mechanism from a structural perspective. Therefore, it has been concluded that MP-V1 is a de novo type of mastoparan with superior antimicrobial activities against both pathogenic bacteria and fungi, which may be useful in developing multipurpose antimicrobial drugs against infectious diseases."xsd:string |
| http://purl.uniprot.org/citations/27104500 | http://purl.org/dc/terms/identifier | "doi:10.3390/molecules21040512"xsd:string |
| http://purl.uniprot.org/citations/27104500 | http://purl.org/dc/terms/identifier | "doi:10.3390/molecules21040512"xsd:string |
| http://purl.uniprot.org/citations/27104500 | http://purl.uniprot.org/core/author | "Kim Y."xsd:string |
| http://purl.uniprot.org/citations/27104500 | http://purl.uniprot.org/core/author | "Kim Y."xsd:string |
| http://purl.uniprot.org/citations/27104500 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/27104500 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/27104500 | http://purl.uniprot.org/core/author | "Park C."xsd:string |
| http://purl.uniprot.org/citations/27104500 | http://purl.uniprot.org/core/author | "Park C."xsd:string |
| http://purl.uniprot.org/citations/27104500 | http://purl.uniprot.org/core/author | "Lee K.W."xsd:string |
| http://purl.uniprot.org/citations/27104500 | http://purl.uniprot.org/core/author | "Lee K.W."xsd:string |
| http://purl.uniprot.org/citations/27104500 | http://purl.uniprot.org/core/author | "Kim C."xsd:string |
| http://purl.uniprot.org/citations/27104500 | http://purl.uniprot.org/core/author | "Kim C."xsd:string |
| http://purl.uniprot.org/citations/27104500 | http://purl.uniprot.org/core/author | "Son M."xsd:string |
| http://purl.uniprot.org/citations/27104500 | http://purl.uniprot.org/core/author | "Son M."xsd:string |
| http://purl.uniprot.org/citations/27104500 | http://purl.uniprot.org/core/author | "Yeo J.H."xsd:string |
| http://purl.uniprot.org/citations/27104500 | http://purl.uniprot.org/core/author | "Yeo J.H."xsd:string |
| http://purl.uniprot.org/citations/27104500 | http://purl.uniprot.org/core/author | "Bang W.Y."xsd:string |
| http://purl.uniprot.org/citations/27104500 | http://purl.uniprot.org/core/author | "Bang W.Y."xsd:string |
| http://purl.uniprot.org/citations/27104500 | http://purl.uniprot.org/core/author | "Noh E.Y."xsd:string |
| http://purl.uniprot.org/citations/27104500 | http://purl.uniprot.org/core/author | "Noh E.Y."xsd:string |
| http://purl.uniprot.org/citations/27104500 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27104500 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |