| http://purl.uniprot.org/citations/27104746 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27104746 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27104746 | http://www.w3.org/2000/01/rdf-schema#comment | "Intestinal divisions in Caenorhabditis elegans take place in 3 stages: (1) cell divisions during embryogenesis, (2) binucleations at the L1 stage, and (3) endoreduplications at the end of each larval stage. Here, we report that CDC-25.2, a C. elegans ortholog of Cdc25, is required for these specialized division cycles between the 16E cell stage and the onset of endoreduplication. Results of our genetic analyses suggest that CDC-25.2 regulates intestinal cell divisions and binucleations by counteracting WEE-1.3 and by activating the CDK-1/CYB-1 complex. CDC-25.2 activity is then repressed by LIN-23 E3 ubiquitin ligase before the onset of intestinal endoreduplication, and this repression is maintained by LIN-35, the C. elegans ortholog of Retinoblastoma (Rb). These findings indicate that timely regulation of CDC-25.2 activity is essential for the progression of specialized division cycles and development of the C. elegans intestine."xsd:string |
| http://purl.uniprot.org/citations/27104746 | http://purl.org/dc/terms/identifier | "doi:10.1080/15384101.2016.1146839"xsd:string |
| http://purl.uniprot.org/citations/27104746 | http://purl.org/dc/terms/identifier | "doi:10.1080/15384101.2016.1146839"xsd:string |
| http://purl.uniprot.org/citations/27104746 | http://purl.uniprot.org/core/author | "Kim J."xsd:string |
| http://purl.uniprot.org/citations/27104746 | http://purl.uniprot.org/core/author | "Kim J."xsd:string |
| http://purl.uniprot.org/citations/27104746 | http://purl.uniprot.org/core/author | "Son M."xsd:string |
| http://purl.uniprot.org/citations/27104746 | http://purl.uniprot.org/core/author | "Son M."xsd:string |
| http://purl.uniprot.org/citations/27104746 | http://purl.uniprot.org/core/author | "Kawasaki I."xsd:string |
| http://purl.uniprot.org/citations/27104746 | http://purl.uniprot.org/core/author | "Kawasaki I."xsd:string |
| http://purl.uniprot.org/citations/27104746 | http://purl.uniprot.org/core/author | "Shim Y.H."xsd:string |
| http://purl.uniprot.org/citations/27104746 | http://purl.uniprot.org/core/author | "Shim Y.H."xsd:string |
| http://purl.uniprot.org/citations/27104746 | http://purl.uniprot.org/core/author | "Lee Y.U."xsd:string |
| http://purl.uniprot.org/citations/27104746 | http://purl.uniprot.org/core/author | "Lee Y.U."xsd:string |
| http://purl.uniprot.org/citations/27104746 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27104746 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27104746 | http://purl.uniprot.org/core/name | "Cell Cycle"xsd:string |
| http://purl.uniprot.org/citations/27104746 | http://purl.uniprot.org/core/name | "Cell Cycle"xsd:string |
| http://purl.uniprot.org/citations/27104746 | http://purl.uniprot.org/core/pages | "654-666"xsd:string |
| http://purl.uniprot.org/citations/27104746 | http://purl.uniprot.org/core/pages | "654-666"xsd:string |
| http://purl.uniprot.org/citations/27104746 | http://purl.uniprot.org/core/title | "CDC-25.2, a C. elegans ortholog of cdc25, is essential for the progression of intestinal divisions."xsd:string |
| http://purl.uniprot.org/citations/27104746 | http://purl.uniprot.org/core/title | "CDC-25.2, a C. elegans ortholog of cdc25, is essential for the progression of intestinal divisions."xsd:string |
| http://purl.uniprot.org/citations/27104746 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/27104746 | http://purl.uniprot.org/core/volume | "15"xsd:string |