| http://purl.uniprot.org/citations/27105115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27105115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27105115 | http://www.w3.org/2000/01/rdf-schema#comment | "Here we report the identification and verification of a β-hydroxybutyrate-derived protein modification, lysine β-hydroxybutyrylation (Kbhb), as a new type of histone mark. Histone Kbhb marks are dramatically induced in response to elevated β-hydroxybutyrate levels in cultured cells and in livers from mice subjected to prolonged fasting or streptozotocin-induced diabetic ketoacidosis. In total, we identified 44 histone Kbhb sites, a figure comparable to the known number of histone acetylation sites. By ChIP-seq and RNA-seq analysis, we demonstrate that histone Kbhb is a mark enriched in active gene promoters and that the increased H3K9bhb levels that occur during starvation are associated with genes upregulated in starvation-responsive metabolic pathways. Histone β-hydroxybutyrylation thus represents a new epigenetic regulatory mark that couples metabolism to gene expression, offering a new avenue to study chromatin regulation and diverse functions of β-hydroxybutyrate in the context of important human pathophysiological states, including diabetes, epilepsy, and neoplasia."xsd:string |
| http://purl.uniprot.org/citations/27105115 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2016.03.036"xsd:string |
| http://purl.uniprot.org/citations/27105115 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2016.03.036"xsd:string |
| http://purl.uniprot.org/citations/27105115 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/27105115 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/27105115 | http://purl.uniprot.org/core/author | "Dai L."xsd:string |
| http://purl.uniprot.org/citations/27105115 | http://purl.uniprot.org/core/author | "Dai L."xsd:string |
| http://purl.uniprot.org/citations/27105115 | http://purl.uniprot.org/core/author | "Huang H."xsd:string |
| http://purl.uniprot.org/citations/27105115 | http://purl.uniprot.org/core/author | "Huang H."xsd:string |
| http://purl.uniprot.org/citations/27105115 | http://purl.uniprot.org/core/author | "Lee S."xsd:string |
| http://purl.uniprot.org/citations/27105115 | http://purl.uniprot.org/core/author | "Lee S."xsd:string |
| http://purl.uniprot.org/citations/27105115 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/27105115 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/27105115 | http://purl.uniprot.org/core/author | "Lombard D.B."xsd:string |
| http://purl.uniprot.org/citations/27105115 | http://purl.uniprot.org/core/author | "Lombard D.B."xsd:string |
| http://purl.uniprot.org/citations/27105115 | http://purl.uniprot.org/core/author | "Li J.'"xsd:string |
| http://purl.uniprot.org/citations/27105115 | http://purl.uniprot.org/core/author | "Li J.'"xsd:string |
| http://purl.uniprot.org/citations/27105115 | http://purl.uniprot.org/core/author | "Peng C."xsd:string |
| http://purl.uniprot.org/citations/27105115 | http://purl.uniprot.org/core/author | "Peng C."xsd:string |
| http://purl.uniprot.org/citations/27105115 | http://purl.uniprot.org/core/author | "Qi S."xsd:string |
| http://purl.uniprot.org/citations/27105115 | http://purl.uniprot.org/core/author | "Qi S."xsd:string |
| http://purl.uniprot.org/citations/27105115 | http://purl.uniprot.org/core/author | "Tan M."xsd:string |
| http://purl.uniprot.org/citations/27105115 | http://purl.uniprot.org/core/author | "Tan M."xsd:string |