| http://purl.uniprot.org/citations/27105498 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27105498 | http://www.w3.org/2000/01/rdf-schema#comment | "Stabilin-1 is a multifunctional scavenger receptor expressed on alternatively-activated macrophages. Stabilin-1 mediates phagocytosis of "unwanted-self" components, intracellular sorting, and endocytic clearance of extracellular ligands including SPARC that modulates breast cancer growth. The expression of stabilin-1 was found on tumor-associated macrophages (TAM) in mouse and human cancers including melanoma, lymphoma, glioblastoma, and pancreatic insulinoma. Despite its tumor-promoting role in mouse models of melanoma and lymphoma the expression and functional role of stabilin-1 in breast cancer was unknown. Here, we demonstrate that stabilin-1 is expressed on TAM in human breast cancer, and its expression is most pronounced on stage I disease. Using stabilin-1 knockout (ko) mice we show that stabilin-1 facilitates growth of mouse TS/A mammary adenocarcinoma. Endocytosis assay on stabilin-1 ko TAM demonstrated impaired clearance of stabilin-1 ligands including SPARC that was capable of inducing cell death in TS/A cells. Affymetrix microarray analysis on purified TAM and reporter assays in stabilin-1 expressing cell lines demonstrated no influence of stabilin-1 expression on intracellular signalling. Our results suggest stabilin-1 mediated silent clearance of extracellular tumor growth-inhibiting factors (e.g. SPARC) as a mechanism of stabilin-1 induced tumor growth. Silent clearance function of stabilin-1 makes it an attractive candidate for delivery of immunomodulatory anti-cancer therapeutic drugs to TAM."xsd:string |
| http://purl.uniprot.org/citations/27105498 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.8857"xsd:string |
| http://purl.uniprot.org/citations/27105498 | http://purl.uniprot.org/core/author | "Song B."xsd:string |
| http://purl.uniprot.org/citations/27105498 | http://purl.uniprot.org/core/author | "Yin S."xsd:string |
| http://purl.uniprot.org/citations/27105498 | http://purl.uniprot.org/core/author | "Arnold B."xsd:string |
| http://purl.uniprot.org/citations/27105498 | http://purl.uniprot.org/core/author | "Marx A."xsd:string |
| http://purl.uniprot.org/citations/27105498 | http://purl.uniprot.org/core/author | "Schledzewski K."xsd:string |
| http://purl.uniprot.org/citations/27105498 | http://purl.uniprot.org/core/author | "Weiss C."xsd:string |
| http://purl.uniprot.org/citations/27105498 | http://purl.uniprot.org/core/author | "Kzhyshkowska J."xsd:string |
| http://purl.uniprot.org/citations/27105498 | http://purl.uniprot.org/core/author | "Goerdt S."xsd:string |
| http://purl.uniprot.org/citations/27105498 | http://purl.uniprot.org/core/author | "Sticht C."xsd:string |
| http://purl.uniprot.org/citations/27105498 | http://purl.uniprot.org/core/author | "Gratchev A."xsd:string |
| http://purl.uniprot.org/citations/27105498 | http://purl.uniprot.org/core/author | "Schmuttermaier C."xsd:string |
| http://purl.uniprot.org/citations/27105498 | http://purl.uniprot.org/core/author | "Fields A.P."xsd:string |
| http://purl.uniprot.org/citations/27105498 | http://purl.uniprot.org/core/author | "Pfister F."xsd:string |
| http://purl.uniprot.org/citations/27105498 | http://purl.uniprot.org/core/author | "Riabov V."xsd:string |
| http://purl.uniprot.org/citations/27105498 | http://purl.uniprot.org/core/author | "Schonhaber H."xsd:string |
| http://purl.uniprot.org/citations/27105498 | http://purl.uniprot.org/core/author | "Simon-Keller K."xsd:string |
| http://purl.uniprot.org/citations/27105498 | http://purl.uniprot.org/core/author | "Avdic A."xsd:string |
| http://purl.uniprot.org/citations/27105498 | http://purl.uniprot.org/core/author | "Berlit S."xsd:string |
| http://purl.uniprot.org/citations/27105498 | http://purl.uniprot.org/core/author | "Llopis Verdiell M."xsd:string |
| http://purl.uniprot.org/citations/27105498 | http://purl.uniprot.org/core/author | "Ovsiy I."xsd:string |
| http://purl.uniprot.org/citations/27105498 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27105498 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |