| http://purl.uniprot.org/citations/27105524 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27105524 | http://www.w3.org/2000/01/rdf-schema#comment | "NLRP12 is a member of the Nod-like receptor (NLR). Previous studies have reported enhanced colitis-associated inflammatory responses in NLRP12-deficient mice. In this study, we sought to investigate the role of NLRP12 in DSS-stimulated proinflammatory response in dendritic cells and mice colitis, and the molecular mechanisms involved in the development of the inflammation. Our results showed that down-regulation of NLRP12 is required for DSS-induced release of proinflammatory cytokines IL-1β and TNF-α; that PR domain zinc finger protein 1 (also known as Blimp-1) induces NLRP12 down-regulation during DSS-induced proinflammatory response and colitis; and that TLR4 is implicated in the up-regulation of Blimp-1 that led to the down-regulation of NLRP12 expression in DSS-induced colitis. Taken together, the results suggest that the TLR4-Blimp-1 axis promotes DSS induced experimental colitis through the down-regulation of NLRP12."xsd:string |
| http://purl.uniprot.org/citations/27105524 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.8872"xsd:string |
| http://purl.uniprot.org/citations/27105524 | http://purl.uniprot.org/core/author | "Hu S."xsd:string |
| http://purl.uniprot.org/citations/27105524 | http://purl.uniprot.org/core/author | "Xu W."xsd:string |
| http://purl.uniprot.org/citations/27105524 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/27105524 | http://purl.uniprot.org/core/author | "Wang T."xsd:string |
| http://purl.uniprot.org/citations/27105524 | http://purl.uniprot.org/core/author | "Shi F."xsd:string |
| http://purl.uniprot.org/citations/27105524 | http://purl.uniprot.org/core/author | "Kouadir M."xsd:string |
| http://purl.uniprot.org/citations/27105524 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27105524 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/27105524 | http://purl.uniprot.org/core/pages | "30575-30584"xsd:string |
| http://purl.uniprot.org/citations/27105524 | http://purl.uniprot.org/core/title | "Inflammasome-independent role of NLRP12 in suppressing colonic inflammation regulated by Blimp-1."xsd:string |
| http://purl.uniprot.org/citations/27105524 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/27105524 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27105524 |
| http://purl.uniprot.org/citations/27105524 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27105524 |
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