| http://purl.uniprot.org/citations/27105925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27105925 | http://www.w3.org/2000/01/rdf-schema#comment | "Stroke has emerged as the second commonest cause of mortality worldwide and is a major public health problem. For the first time, we present here the association of human leucocyte antigen (HLA)-DRB1*/DQB1* alleles and haplotypes with ischaemic stroke in South Indian patients. Ischaemic stroke (IS) cases and controls were genotyped for HLA-DRB1*/DQB1* alleles by polymerase chain reaction sequence-specific primers (PCR-SSP) method. The frequencies of HLA class II alleles such as DRB1*04, DRB1*07, DRB1*11, DRB1*12, DRB1*13, DQB1*02 and DQB1*07 were high in IS patients than in the age- and gender-matched controls, suggesting that the individuals with these alleles are susceptible to ischaemic stroke in South India. The frequencies of alleles such as DRB1*03, DRB1*10, DRB1*14, DQB1*04 and DQB1*05 were less in IS cases than in the controls, suggesting a protective association. Haplotypes DRB1*04-DQB1*0301, DRB1*07-DQB1*02, DRB1*07-DQB1*0301, DRB1*11-DQB1*0301 and DRB1*13-DQB1*06 were found to be high in IS patients conferring susceptibility. The frequency of haplotype DRB1*10-DQB1*05 was high in controls conferring protection. IS-LVD and gender-stratified analysis too confirmed these susceptible and protective associations. Thus, HLA-DRB1*/DQB1* alleles and haplotypes strongly predispose South Indian population to ischaemic stroke. Further studies in different populations with large sample size or the meta-analysis are needed to explain the exact mechanism of associations of HLA gene(s) with IS."xsd:string |
| http://purl.uniprot.org/citations/27105925 | http://purl.org/dc/terms/identifier | "doi:10.1111/iji.12266"xsd:string |
| http://purl.uniprot.org/citations/27105925 | http://purl.uniprot.org/core/author | "Balakrishnan K."xsd:string |
| http://purl.uniprot.org/citations/27105925 | http://purl.uniprot.org/core/author | "Arun Kumar M.J."xsd:string |
| http://purl.uniprot.org/citations/27105925 | http://purl.uniprot.org/core/author | "Jeyaram Illiayaraja K."xsd:string |
| http://purl.uniprot.org/citations/27105925 | http://purl.uniprot.org/core/author | "Murali V."xsd:string |
| http://purl.uniprot.org/citations/27105925 | http://purl.uniprot.org/core/author | "Neethi Arasu V."xsd:string |
| http://purl.uniprot.org/citations/27105925 | http://purl.uniprot.org/core/author | "Padma Malini R."xsd:string |
| http://purl.uniprot.org/citations/27105925 | http://purl.uniprot.org/core/author | "Ramgopal S."xsd:string |
| http://purl.uniprot.org/citations/27105925 | http://purl.uniprot.org/core/author | "Rathika C."xsd:string |
| http://purl.uniprot.org/citations/27105925 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27105925 | http://purl.uniprot.org/core/name | "Int J Immunogenet"xsd:string |
| http://purl.uniprot.org/citations/27105925 | http://purl.uniprot.org/core/pages | "159-165"xsd:string |
| http://purl.uniprot.org/citations/27105925 | http://purl.uniprot.org/core/title | "Susceptible and protective associations of HLA DRB1*/DQB1* alleles and haplotypes with ischaemic stroke."xsd:string |
| http://purl.uniprot.org/citations/27105925 | http://purl.uniprot.org/core/volume | "43"xsd:string |
| http://purl.uniprot.org/citations/27105925 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27105925 |
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| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-27105925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27105925 |
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| http://purl.uniprot.org/uniprot/#_A0A0A7C7I5-mappedCitation-27105925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27105925 |