| http://purl.uniprot.org/citations/27108704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27108704 | http://www.w3.org/2000/01/rdf-schema#comment | "Cell adhesion molecules (CAMs) are involved in various immune-mediated diseases. This study was conducted to investigate the association of single nucleotide polymorphisms (SNPs) of CAMs with Behçet's disease (BD) in a Chinese Han population. A two-stage association study was carried out in 1149 BD patients and 2107 normal controls. Genotyping of 43 SNPs was performed using MassARRAY System (Sequenom), polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and TaqMan SNP assays. The expression of CD6 and CD11c was examined by real-time PCR and cytokine production was measured by ELISA. A significantly higher frequency of the CT genotype, and a lower frequency of the CC genotype and C allele of CD6 rs11230563 were observed in BD as compared with controls. Analysis of CD11c rs2929 showed that patients with BD had a significantly higher frequency of the GG genotype and G allele, and a lower frequency of the AG genotype as compared with controls. Functional experiments showed an increased CD11c expression and increased production of TNF-α and IL-1beta by LPS stimulated PBMCs in GG carriers of CD11c rs2929 compared to AA/AG carriers. Our study provides evidence that CD6 and CD11c are involved in the susceptibility to BD in a Chinese Han population."xsd:string |
| http://purl.uniprot.org/citations/27108704 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep24974"xsd:string |
| http://purl.uniprot.org/citations/27108704 | http://purl.uniprot.org/core/author | "Huang Y."xsd:string |
| http://purl.uniprot.org/citations/27108704 | http://purl.uniprot.org/core/author | "Huang G."xsd:string |
| http://purl.uniprot.org/citations/27108704 | http://purl.uniprot.org/core/author | "Hu J."xsd:string |
| http://purl.uniprot.org/citations/27108704 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/27108704 | http://purl.uniprot.org/core/author | "Yu H."xsd:string |
| http://purl.uniprot.org/citations/27108704 | http://purl.uniprot.org/core/author | "Zheng M."xsd:string |
| http://purl.uniprot.org/citations/27108704 | http://purl.uniprot.org/core/author | "Yang P."xsd:string |
| http://purl.uniprot.org/citations/27108704 | http://purl.uniprot.org/core/author | "Cao Q."xsd:string |
| http://purl.uniprot.org/citations/27108704 | http://purl.uniprot.org/core/author | "Yuan G."xsd:string |
| http://purl.uniprot.org/citations/27108704 | http://purl.uniprot.org/core/author | "Kijlstra A."xsd:string |
| http://purl.uniprot.org/citations/27108704 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27108704 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/27108704 | http://purl.uniprot.org/core/pages | "24974"xsd:string |
| http://purl.uniprot.org/citations/27108704 | http://purl.uniprot.org/core/title | "Genetic polymorphisms of cell adhesion molecules in Behcet's disease in a Chinese Han population."xsd:string |
| http://purl.uniprot.org/citations/27108704 | http://purl.uniprot.org/core/volume | "6"xsd:string |
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