| http://purl.uniprot.org/citations/27109382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27109382 | http://www.w3.org/2000/01/rdf-schema#comment | "lipid metabolism is the major causes of atherosclerosis. There is increasing evidence that miR-133a plays an important role in atherosclerosis. However, the regulatory mechanism of miR-133a in macrophages is still unclear. Several lines of evidence indicate that loss of TR4 leads to reduce lipid accumulation in liver and adipose tissues, etc, and lesional macrophages-derived TR4 can greatly increase the foam cell formation through increasing the CD36-mediated the uptake of ox-LDL. Interestingly, computational analysis suggests that TR4 may be a target gene of miR-133a. Here, we examined whether miR-133a regulates TR4 expression in ox-LDL-induced mouse RAW 264.7 macrophages, thereby affecting lipid accumulation. Using ox-LDL-treatment RAW 264.7 macrophages transfected with miR-133a mimics or inhibitors, we have showed that miR-133a can directly regulate the expression of TR4 in RAW 264.7 cells, thereby attenuates CD36-medide lipid accumulation. Furthermore, our studies suggest an additional explanation for the regulatory mechanism of miR-133a regulation to its functional target, TR4 in RAW 264.7 macrophages. Thus, our findings suggest that miR-133a may regulate lipid accumulation in ox-LDL-stimulated RAW 264.7 macrophages via TR4-CD36 pathway."xsd:string |
| http://purl.uniprot.org/citations/27109382 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.biochi.2016.04.012"xsd:string |
| http://purl.uniprot.org/citations/27109382 | http://purl.uniprot.org/core/author | "Huang L."xsd:string |
| http://purl.uniprot.org/citations/27109382 | http://purl.uniprot.org/core/author | "Liu Z.H."xsd:string |
| http://purl.uniprot.org/citations/27109382 | http://purl.uniprot.org/core/author | "Peng X.P."xsd:string |
| http://purl.uniprot.org/citations/27109382 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27109382 | http://purl.uniprot.org/core/name | "Biochimie"xsd:string |
| http://purl.uniprot.org/citations/27109382 | http://purl.uniprot.org/core/pages | "79-85"xsd:string |
| http://purl.uniprot.org/citations/27109382 | http://purl.uniprot.org/core/title | "miRNA-133a attenuates lipid accumulation via TR4-CD36 pathway in macrophages."xsd:string |
| http://purl.uniprot.org/citations/27109382 | http://purl.uniprot.org/core/volume | "127"xsd:string |
| http://purl.uniprot.org/citations/27109382 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27109382 |
| http://purl.uniprot.org/citations/27109382 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27109382 |
| http://purl.uniprot.org/uniprot/#_P49117-mappedCitation-27109382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27109382 |
| http://purl.uniprot.org/uniprot/#_E7D893-mappedCitation-27109382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27109382 |
| http://purl.uniprot.org/uniprot/#_G3X9W4-mappedCitation-27109382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27109382 |
| http://purl.uniprot.org/uniprot/#_Q3ZAR9-mappedCitation-27109382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27109382 |
| http://purl.uniprot.org/uniprot/#_Q3ZAS1-mappedCitation-27109382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27109382 |
| http://purl.uniprot.org/uniprot/#_Q3U6Y9-mappedCitation-27109382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27109382 |
| http://purl.uniprot.org/uniprot/#_Q08857-mappedCitation-27109382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27109382 |
| http://purl.uniprot.org/uniprot/#_Q3UC79-mappedCitation-27109382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27109382 |
| http://purl.uniprot.org/uniprot/#_Q3TA14-mappedCitation-27109382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27109382 |
| http://purl.uniprot.org/uniprot/#_Q5DTL3-mappedCitation-27109382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27109382 |
| http://purl.uniprot.org/uniprot/#_Q3U015-mappedCitation-27109382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27109382 |
| http://purl.uniprot.org/uniprot/#_Q3UAI3-mappedCitation-27109382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27109382 |