| http://purl.uniprot.org/citations/27111588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27111588 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundThe high homology and opposite orientation of RH genes promote rearrangements between them and generate a large number of RHD and RHCE variants which can be inherited together. Searching of RHD-CE genotypes predicting partial antigens in donors is of interest in order to find more closely matched donors for African descent patients. This study aimed to evaluate a molecular approach to search for RhCE variants in a cohort of individuals with altered expression of D antigen and determine the association of RH variant alleles in Brazilian blood donors.MethodsFrom 80,961 blood samples tested, 421 with atypical D typing results were studied. The samples were phenotyped for C, c, E, e antigens. Rh variants were identified using molecular techniques.ResultsAll 421 samples had altered RHD alleles, being 56·3% of them partial D. Among them, 94·9% presented variant RHCE*ce and the most common associations were: RHD*weak D type 4.2.2 with RHCE*ceAR; RHD*DAR linked to RHCE*ceVS.02; RHD*weak D type 4.0 linked to RHCE*ceVS.02 and RHCE*ce (c.48C, c.105T, c.733G, c.744C, c.1025T). Among the samples with RhCE variants, 10·6% predict partial c, partial e, hr(B) - and/or hr(S) - and 100% express low prevalence antigens.ConclusionTargeting individuals with altered expression of D antigen can be a good strategy for finding donors with RhCE variants. In our study 94·9% of the partial D samples revealed altered RHCE variant alleles and 5·7% of the samples with altered RHD allele predicted partial c, partial e and the lack of the high prevalence hr(B) and hr(S) antigens."xsd:string |
| http://purl.uniprot.org/citations/27111588 | http://purl.org/dc/terms/identifier | "doi:10.1111/tme.12309"xsd:string |
| http://purl.uniprot.org/citations/27111588 | http://purl.uniprot.org/core/author | "Castilho L."xsd:string |
| http://purl.uniprot.org/citations/27111588 | http://purl.uniprot.org/core/author | "de Medeiros Person R."xsd:string |
| http://purl.uniprot.org/citations/27111588 | http://purl.uniprot.org/core/author | "de Paula Vendrame T.A."xsd:string |
| http://purl.uniprot.org/citations/27111588 | http://purl.uniprot.org/core/author | "Guilhem Muniz J."xsd:string |
| http://purl.uniprot.org/citations/27111588 | http://purl.uniprot.org/core/author | "Prisco Arnoni C."xsd:string |
| http://purl.uniprot.org/citations/27111588 | http://purl.uniprot.org/core/author | "Roche Moreira Latini F."xsd:string |
| http://purl.uniprot.org/citations/27111588 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27111588 | http://purl.uniprot.org/core/name | "Transfus Med"xsd:string |
| http://purl.uniprot.org/citations/27111588 | http://purl.uniprot.org/core/pages | "285-290"xsd:string |
| http://purl.uniprot.org/citations/27111588 | http://purl.uniprot.org/core/title | "RHCE variants inherited with altered RHD alleles in Brazilian blood donors."xsd:string |
| http://purl.uniprot.org/citations/27111588 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/27111588 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27111588 |
| http://purl.uniprot.org/citations/27111588 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27111588 |
| http://purl.uniprot.org/uniprot/#_A0A089VLV6-mappedCitation-27111588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27111588 |
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| http://purl.uniprot.org/uniprot/#_A0A078BQE0-mappedCitation-27111588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27111588 |
| http://purl.uniprot.org/uniprot/#_A0A078N0E5-mappedCitation-27111588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27111588 |
| http://purl.uniprot.org/uniprot/#_A0A0K0QTI0-mappedCitation-27111588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27111588 |
| http://purl.uniprot.org/uniprot/#_A0A0D3QSK8-mappedCitation-27111588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27111588 |
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