| http://purl.uniprot.org/citations/27120784 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27120784 | http://www.w3.org/2000/01/rdf-schema#comment | "The miR-145-5p, which induces TP53-dependent apoptosis, is down-regulated in several tumors, including hepatocellular carcinomas (HCCs), but some HCCs show physiological expression of this miR. Here we demonstrate that in HCC cells carrying wild-type TP53 the steady activation of the miR-145 signaling selects clones resistant to apoptosis via up-regulation of the oncogenic miR-483-3p. Expression of the miR-145-5p and of the miR-483-3p correlated negatively in non-neoplastic liver (n=41; ρ=-0.342, P=0.028), but positively in HCCs (n=21; ρ=0.791, P<0.0001), which we hypothesized to be due to impaired glucose metabolism in HCCs versus normal liver. In fact, when liver cancer cells were grown in low glucose, miR-145-5p lowered miR-483-3p expression, allowing apoptosis, whereas when cells were grown in high glucose the levels of miR-483-3p increased, reducing the apoptotic rate. This indicates that depending on glucose availability the miR-145-5p has double effects on the miR-483-3p, either inhibitory or stimulatory. Moreover, resistance to apoptosis in clones overexpressing both miR-145-5p and miR-483-3p was abrogated by silencing the miR-483-3p. Our data highlight a novel mechanism of resistance to apoptosis in liver cancer cells harbouring wild type TP53 and suggest a potential role of miR-145-5p and miR-483-3p as druggable targets in a subset of HCCs."xsd:string |
| http://purl.uniprot.org/citations/27120784 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.8913"xsd:string |
| http://purl.uniprot.org/citations/27120784 | http://purl.uniprot.org/core/author | "Calin G.A."xsd:string |
| http://purl.uniprot.org/citations/27120784 | http://purl.uniprot.org/core/author | "Ferracin M."xsd:string |
| http://purl.uniprot.org/citations/27120784 | http://purl.uniprot.org/core/author | "Negrini M."xsd:string |
| http://purl.uniprot.org/citations/27120784 | http://purl.uniprot.org/core/author | "Sabbioni S."xsd:string |
| http://purl.uniprot.org/citations/27120784 | http://purl.uniprot.org/core/author | "Veronese A."xsd:string |
| http://purl.uniprot.org/citations/27120784 | http://purl.uniprot.org/core/author | "Mariani-Costantini R."xsd:string |
| http://purl.uniprot.org/citations/27120784 | http://purl.uniprot.org/core/author | "Visone R."xsd:string |
| http://purl.uniprot.org/citations/27120784 | http://purl.uniprot.org/core/author | "Lupini L."xsd:string |
| http://purl.uniprot.org/citations/27120784 | http://purl.uniprot.org/core/author | "Callegari E."xsd:string |
| http://purl.uniprot.org/citations/27120784 | http://purl.uniprot.org/core/author | "Lanuti P."xsd:string |
| http://purl.uniprot.org/citations/27120784 | http://purl.uniprot.org/core/author | "Ghasemi R."xsd:string |
| http://purl.uniprot.org/citations/27120784 | http://purl.uniprot.org/core/author | "Spizzo R."xsd:string |
| http://purl.uniprot.org/citations/27120784 | http://purl.uniprot.org/core/author | "Bolondi L."xsd:string |
| http://purl.uniprot.org/citations/27120784 | http://purl.uniprot.org/core/author | "Gramantieri L."xsd:string |
| http://purl.uniprot.org/citations/27120784 | http://purl.uniprot.org/core/author | "Fornari F."xsd:string |
| http://purl.uniprot.org/citations/27120784 | http://purl.uniprot.org/core/author | "Braconi C."xsd:string |
| http://purl.uniprot.org/citations/27120784 | http://purl.uniprot.org/core/author | "Zagatti B."xsd:string |
| http://purl.uniprot.org/citations/27120784 | http://purl.uniprot.org/core/author | "Pepe F."xsd:string |
| http://purl.uniprot.org/citations/27120784 | http://purl.uniprot.org/core/author | "Pagotto S."xsd:string |
| http://purl.uniprot.org/citations/27120784 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27120784 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/27120784 | http://purl.uniprot.org/core/pages | "31361-31371"xsd:string |