| http://purl.uniprot.org/citations/27121396 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27121396 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent microRNA expression profiling studies have documented an up-regulation of miR-146a in several angiogenesis models. However, the underlying molecular mechanism of miR-146a in the angiogenic activity of endothelial cells has not been clearly elucidated. The present study was aimed to evaluate whether miR-146a promotes angiogenesis in HUVECs by increasing FGFBP1 expression via directly targeting CREB3L1. miR-146a was over expressed in HUVECs via lentiviral-miR-146a. Expression profiling analysis found miR-146a over expression resulted in up-regulation of angiogenesis and cytokine activity associated genes including FGF2. Further a combination of bioinformatics and experimental analyses demonstrated the CREB3L1 as a bona fide functional target of miR-146a during angiogenesis. Moreover, CREB3L1 inhibited luciferase expression from FGFBP1 promoter containing only CRE elements. Furthermore, CREB3L1 inhibited FGFBP1 expression by binding to two CRE-like sites located at approximately -1780-1777 and -868-865 bp relative to the FGFBP1 transcription start site. Additionally, ectopic expression of CREB3L1 decreased miR-146a-induced FGF2 secretion. These findings indicate that the miR-146a-CREB3L1-FGFBP1 signaling axis plays an important role in the regulation of angiogenesis in HUVECs and provides a potential therapeutic target for anti-angiogenic therapeutics."xsd:string |
| http://purl.uniprot.org/citations/27121396 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep25272"xsd:string |
| http://purl.uniprot.org/citations/27121396 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/27121396 | http://purl.uniprot.org/core/author | "Li N."xsd:string |
| http://purl.uniprot.org/citations/27121396 | http://purl.uniprot.org/core/author | "Liu J.Q."xsd:string |
| http://purl.uniprot.org/citations/27121396 | http://purl.uniprot.org/core/author | "Zhou Q."xsd:string |
| http://purl.uniprot.org/citations/27121396 | http://purl.uniprot.org/core/author | "Zhang Y.J."xsd:string |
| http://purl.uniprot.org/citations/27121396 | http://purl.uniprot.org/core/author | "Zheng Z."xsd:string |
| http://purl.uniprot.org/citations/27121396 | http://purl.uniprot.org/core/author | "Zhu H.Y."xsd:string |
| http://purl.uniprot.org/citations/27121396 | http://purl.uniprot.org/core/author | "Wang Y.C."xsd:string |
| http://purl.uniprot.org/citations/27121396 | http://purl.uniprot.org/core/author | "Guan H."xsd:string |
| http://purl.uniprot.org/citations/27121396 | http://purl.uniprot.org/core/author | "Wang H.T."xsd:string |
| http://purl.uniprot.org/citations/27121396 | http://purl.uniprot.org/core/author | "Xie S.T."xsd:string |
| http://purl.uniprot.org/citations/27121396 | http://purl.uniprot.org/core/author | "Hu D.H."xsd:string |
| http://purl.uniprot.org/citations/27121396 | http://purl.uniprot.org/core/author | "Su L.L."xsd:string |
| http://purl.uniprot.org/citations/27121396 | http://purl.uniprot.org/core/author | "Bai W.D."xsd:string |
| http://purl.uniprot.org/citations/27121396 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27121396 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/27121396 | http://purl.uniprot.org/core/pages | "25272"xsd:string |
| http://purl.uniprot.org/citations/27121396 | http://purl.uniprot.org/core/title | "Up-regulation of FGFBP1 signaling contributes to miR-146a-induced angiogenesis in human umbilical vein endothelial cells."xsd:string |
| http://purl.uniprot.org/citations/27121396 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/27121396 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27121396 |
| http://purl.uniprot.org/citations/27121396 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27121396 |
| http://purl.uniprot.org/uniprot/Q96BA8#attribution-5260223050606887C3EB8F26C18BB8F7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/27121396 |