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| http://purl.uniprot.org/citations/27128386 | http://www.w3.org/2000/01/rdf-schema#comment | "The canonical Wnt/β-catenin signaling pathway plays a pivotal role and is essentially required for the osteoblast differentiation and bone formation. In this study, we found ubiquitin-specific peptidase 4 (USP4) to strongly inhibit the Wnt/β-catenin signaling by removing Lysine-63 linked poly-ubiquitin chain from Dishevelled (Dvl). Ectopic expression of USP4 promoted β-catenin poly-ubiquitination and thus inhibited Wnt-induced accumulation of cytosolic β-catenin and counteracted Wnt-induced transcriptional activity. Moreover, USP4 knockdown or USP4 knockout led to an increase in the active β-catenin levels and in activation of Wnt/β-catenin-induced transcription. Functional studies in C2C12 myoblasts and KS483 osteoprogenitor cells showed that ectopic expression of USP4 resulted in impaired activation of endogenous Wnt3a-induced genes and decreased osteoblast differentiation and mineralization, whereas USP4 depletion showed the opposite effect. These results identify USP4 as a novel regulator of Dvl in Wnt/β-catenin signal and show its involvement in Wnt3a-induced osteoblast differentiation. © 2016 American Society for Bone and Mineral Research."xsd:string |
| http://purl.uniprot.org/citations/27128386 | http://purl.org/dc/terms/identifier | "doi:10.1002/jbmr.2863"xsd:string |
| http://purl.uniprot.org/citations/27128386 | http://purl.uniprot.org/core/author | "Dai T."xsd:string |
| http://purl.uniprot.org/citations/27128386 | http://purl.uniprot.org/core/author | "Jia J."xsd:string |
| http://purl.uniprot.org/citations/27128386 | http://purl.uniprot.org/core/author | "Li F."xsd:string |
| http://purl.uniprot.org/citations/27128386 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/27128386 | http://purl.uniprot.org/core/author | "Zheng M."xsd:string |
| http://purl.uniprot.org/citations/27128386 | http://purl.uniprot.org/core/author | "Yang B."xsd:string |
| http://purl.uniprot.org/citations/27128386 | http://purl.uniprot.org/core/author | "Zhou F."xsd:string |
| http://purl.uniprot.org/citations/27128386 | http://purl.uniprot.org/core/author | "Fang P."xsd:string |
| http://purl.uniprot.org/citations/27128386 | http://purl.uniprot.org/core/author | "van Dam H."xsd:string |
| http://purl.uniprot.org/citations/27128386 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27128386 | http://purl.uniprot.org/core/name | "J Bone Miner Res"xsd:string |
| http://purl.uniprot.org/citations/27128386 | http://purl.uniprot.org/core/pages | "1888-1898"xsd:string |
| http://purl.uniprot.org/citations/27128386 | http://purl.uniprot.org/core/title | "Ubiquitin-Specific Protease 4 Antagonizes Osteoblast Differentiation Through Dishevelled."xsd:string |
| http://purl.uniprot.org/citations/27128386 | http://purl.uniprot.org/core/volume | "31"xsd:string |
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