| http://purl.uniprot.org/citations/27131830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27131830 | http://www.w3.org/2000/01/rdf-schema#comment | "The MC1R gene, suggested to be involved in Parkinson disease (PD) and melanoma, was sequenced in PD patients (n = 539) and controls (n = 265) from New York, and PD patients (n = 551), rapid eye movement sleep behavior disorder (RBD) patients (n = 351), and controls (n = 956) of European ancestry. Sixty-eight MC1R variants were identified, including 7 common variants with frequency > 0.01. None of the common variants was associated with PD or RBD in the different regression models. In a meta-analysis with fixed-effect model, the p.R160W variant was associated with an increased risk for PD (odds ratio = 1.22, 95% confidence interval = 1.02-1.47, p = 0.03) but with significant heterogeneity (p = 0.048). Removing one study that introduced the heterogeneity resulted in nonsignificant association (odds ratio = 1.11, 95% confidence interval, 0.92-1.35, p = 0.27, heterogeneity p = 0.57). Rare variants had similar frequencies in patients and controls (10.54% and 10.15%, respectively, p = 0.75), and no cumulative effect of carrying more than one MC1R variant was found. The present study does not support a role for the MC1R p.R160W and other variants in susceptibility for PD or RBD."xsd:string |
| http://purl.uniprot.org/citations/27131830 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neurobiolaging.2016.03.029"xsd:string |
| http://purl.uniprot.org/citations/27131830 | http://purl.uniprot.org/core/author | "Ambalavanan A."xsd:string |
| http://purl.uniprot.org/citations/27131830 | http://purl.uniprot.org/core/author | "Rouleau G.A."xsd:string |
| http://purl.uniprot.org/citations/27131830 | http://purl.uniprot.org/core/author | "Langlois M."xsd:string |
| http://purl.uniprot.org/citations/27131830 | http://purl.uniprot.org/core/author | "Dupre N."xsd:string |
| http://purl.uniprot.org/citations/27131830 | http://purl.uniprot.org/core/author | "Dion P.A."xsd:string |
| http://purl.uniprot.org/citations/27131830 | http://purl.uniprot.org/core/author | "Gan-Or Z."xsd:string |
| http://purl.uniprot.org/citations/27131830 | http://purl.uniprot.org/core/author | "Laurent S.B."xsd:string |
| http://purl.uniprot.org/citations/27131830 | http://purl.uniprot.org/core/author | "Girard S.L."xsd:string |
| http://purl.uniprot.org/citations/27131830 | http://purl.uniprot.org/core/author | "Bourassa C.V."xsd:string |
| http://purl.uniprot.org/citations/27131830 | http://purl.uniprot.org/core/author | "Mohsin N."xsd:string |
| http://purl.uniprot.org/citations/27131830 | http://purl.uniprot.org/core/author | "Boivin M."xsd:string |
| http://purl.uniprot.org/citations/27131830 | http://purl.uniprot.org/core/author | "Alcalay R.N."xsd:string |
| http://purl.uniprot.org/citations/27131830 | http://purl.uniprot.org/core/author | "Arnulf I."xsd:string |
| http://purl.uniprot.org/citations/27131830 | http://purl.uniprot.org/core/author | "Dauvilliers Y."xsd:string |
| http://purl.uniprot.org/citations/27131830 | http://purl.uniprot.org/core/author | "Desautels A."xsd:string |
| http://purl.uniprot.org/citations/27131830 | http://purl.uniprot.org/core/author | "Gagnon J.F."xsd:string |
| http://purl.uniprot.org/citations/27131830 | http://purl.uniprot.org/core/author | "Montplaisir J.Y."xsd:string |
| http://purl.uniprot.org/citations/27131830 | http://purl.uniprot.org/core/author | "Postuma R.B."xsd:string |
| http://purl.uniprot.org/citations/27131830 | http://purl.uniprot.org/core/author | "Frauscher B."xsd:string |
| http://purl.uniprot.org/citations/27131830 | http://purl.uniprot.org/core/author | "Hogl B."xsd:string |
| http://purl.uniprot.org/citations/27131830 | http://purl.uniprot.org/core/author | "Monaca C."xsd:string |
| http://purl.uniprot.org/citations/27131830 | http://purl.uniprot.org/core/author | "Mallett V."xsd:string |