| http://purl.uniprot.org/citations/27133129 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27133129 | http://www.w3.org/2000/01/rdf-schema#comment | "Despite significant advances in our understanding of the biology determining systemic energy homeostasis, the treatment of obesity remains a medical challenge. Activation of AMP-activated protein kinase (AMPK) has been proposed as an attractive strategy for the treatment of obesity and its complications. AMPK is a conserved, ubiquitously expressed, heterotrimeric serine/threonine kinase whose short-term activation has multiple beneficial metabolic effects. Whether these translate into long-term benefits for obesity and its complications is unknown. Here, we observe that mice with chronic AMPK activation, resulting from mutation of the AMPK γ2 subunit, exhibit ghrelin signaling-dependent hyperphagia, obesity, and impaired pancreatic islet insulin secretion. Humans bearing the homologous mutation manifest a congruent phenotype. Our studies highlight that long-term AMPK activation throughout all tissues can have adverse metabolic consequences, with implications for pharmacological strategies seeking to chronically activate AMPK systemically to treat metabolic disease."xsd:string |
| http://purl.uniprot.org/citations/27133129 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2016.04.003"xsd:string |
| http://purl.uniprot.org/citations/27133129 | http://purl.uniprot.org/core/author | "Nguyen C."xsd:string |
| http://purl.uniprot.org/citations/27133129 | http://purl.uniprot.org/core/author | "Toth M."xsd:string |
| http://purl.uniprot.org/citations/27133129 | http://purl.uniprot.org/core/author | "Heisler L.K."xsd:string |
| http://purl.uniprot.org/citations/27133129 | http://purl.uniprot.org/core/author | "Yeo G.S."xsd:string |
| http://purl.uniprot.org/citations/27133129 | http://purl.uniprot.org/core/author | "Carling D."xsd:string |
| http://purl.uniprot.org/citations/27133129 | http://purl.uniprot.org/core/author | "Woods A."xsd:string |
| http://purl.uniprot.org/citations/27133129 | http://purl.uniprot.org/core/author | "Ashrafian H."xsd:string |
| http://purl.uniprot.org/citations/27133129 | http://purl.uniprot.org/core/author | "Redwood C."xsd:string |
| http://purl.uniprot.org/citations/27133129 | http://purl.uniprot.org/core/author | "Rutter G.A."xsd:string |
| http://purl.uniprot.org/citations/27133129 | http://purl.uniprot.org/core/author | "Watkins H."xsd:string |
| http://purl.uniprot.org/citations/27133129 | http://purl.uniprot.org/core/author | "Pinter K."xsd:string |
| http://purl.uniprot.org/citations/27133129 | http://purl.uniprot.org/core/author | "Harper A.R."xsd:string |
| http://purl.uniprot.org/citations/27133129 | http://purl.uniprot.org/core/author | "Smith M.A."xsd:string |
| http://purl.uniprot.org/citations/27133129 | http://purl.uniprot.org/core/author | "Willows R."xsd:string |
| http://purl.uniprot.org/citations/27133129 | http://purl.uniprot.org/core/author | "Pullen T.J."xsd:string |
| http://purl.uniprot.org/citations/27133129 | http://purl.uniprot.org/core/author | "Ghaffari S."xsd:string |
| http://purl.uniprot.org/citations/27133129 | http://purl.uniprot.org/core/author | "Brown L.A."xsd:string |
| http://purl.uniprot.org/citations/27133129 | http://purl.uniprot.org/core/author | "Oliver P.L."xsd:string |
| http://purl.uniprot.org/citations/27133129 | http://purl.uniprot.org/core/author | "Fekete C."xsd:string |
| http://purl.uniprot.org/citations/27133129 | http://purl.uniprot.org/core/author | "Gereben B."xsd:string |
| http://purl.uniprot.org/citations/27133129 | http://purl.uniprot.org/core/author | "Peirson S.N."xsd:string |
| http://purl.uniprot.org/citations/27133129 | http://purl.uniprot.org/core/author | "Arch J.R."xsd:string |