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| http://purl.uniprot.org/citations/27133166 | http://www.w3.org/2000/01/rdf-schema#comment | "Organisms respond to mitochondrial stress through the upregulation of an array of protective genes, often perpetuating an early response to metabolic dysfunction across a lifetime. We find that mitochondrial stress causes widespread changes in chromatin structure through histone H3K9 di-methylation marks traditionally associated with gene silencing. Mitochondrial stress response activation requires the di-methylation of histone H3K9 through the activity of the histone methyltransferase met-2 and the nuclear co-factor lin-65. While globally the chromatin becomes silenced by these marks, remaining portions of the chromatin open up, at which point the binding of canonical stress responsive factors such as DVE-1 occurs. Thus, a metabolic stress response is established and propagated into adulthood of animals through specific epigenetic modifications that allow for selective gene expression and lifespan extension."xsd:string |
| http://purl.uniprot.org/citations/27133166 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2016.04.011"xsd:string |
| http://purl.uniprot.org/citations/27133166 | http://purl.uniprot.org/core/author | "Tian Y."xsd:string |
| http://purl.uniprot.org/citations/27133166 | http://purl.uniprot.org/core/author | "Garcia G."xsd:string |
| http://purl.uniprot.org/citations/27133166 | http://purl.uniprot.org/core/author | "Dillin A."xsd:string |
| http://purl.uniprot.org/citations/27133166 | http://purl.uniprot.org/core/author | "Meyer B.J."xsd:string |
| http://purl.uniprot.org/citations/27133166 | http://purl.uniprot.org/core/author | "Wolff S."xsd:string |
| http://purl.uniprot.org/citations/27133166 | http://purl.uniprot.org/core/author | "Bian Q."xsd:string |
| http://purl.uniprot.org/citations/27133166 | http://purl.uniprot.org/core/author | "Steffen K.K."xsd:string |
| http://purl.uniprot.org/citations/27133166 | http://purl.uniprot.org/core/author | "Joe L."xsd:string |
| http://purl.uniprot.org/citations/27133166 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27133166 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/27133166 | http://purl.uniprot.org/core/pages | "1197-1208"xsd:string |
| http://purl.uniprot.org/citations/27133166 | http://purl.uniprot.org/core/title | "Mitochondrial Stress Induces Chromatin Reorganization to Promote Longevity and UPR(mt)."xsd:string |
| http://purl.uniprot.org/citations/27133166 | http://purl.uniprot.org/core/volume | "165"xsd:string |
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