| http://purl.uniprot.org/citations/27133466 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27133466 | http://www.w3.org/2000/01/rdf-schema#comment | "Postsynaptic kainate-type glutamate receptors (KARs) regulate synaptic network activity through their slow channel kinetics, most prominently at mossy fiber (MF)-CA3 synapses in the hippocampus. Nevertheless, how KARs cluster and function at these synapses has been unclear. Here, we show that C1q-like proteins C1ql2 and C1ql3, produced by MFs, serve as extracellular organizers to recruit functional postsynaptic KAR complexes to the CA3 pyramidal neurons. C1ql2 and C1ql3 specifically bound the amino-terminal domains of postsynaptic GluK2 and GluK4 KAR subunits and the presynaptic neurexin 3 containing a specific sequence in vitro. In C1ql2/3 double-null mice, CA3 synaptic responses lost the slow, KAR-mediated components. Furthermore, despite induction of MF sprouting in a temporal lobe epilepsy model, KARs were not recruited to postsynaptic sites in C1ql2/3 double-null mice, leading to reduced recurrent circuit activities. C1q family proteins, broadly expressed, are likely to modulate KAR function throughout the brain and represent promising antiepileptic targets."xsd:string |
| http://purl.uniprot.org/citations/27133466 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2016.04.001"xsd:string |
| http://purl.uniprot.org/citations/27133466 | http://purl.uniprot.org/core/author | "Watanabe M."xsd:string |
| http://purl.uniprot.org/citations/27133466 | http://purl.uniprot.org/core/author | "Abe M."xsd:string |
| http://purl.uniprot.org/citations/27133466 | http://purl.uniprot.org/core/author | "Yamasaki M."xsd:string |
| http://purl.uniprot.org/citations/27133466 | http://purl.uniprot.org/core/author | "Matsuda K."xsd:string |
| http://purl.uniprot.org/citations/27133466 | http://purl.uniprot.org/core/author | "Sugaya Y."xsd:string |
| http://purl.uniprot.org/citations/27133466 | http://purl.uniprot.org/core/author | "Konno K."xsd:string |
| http://purl.uniprot.org/citations/27133466 | http://purl.uniprot.org/core/author | "Watanabe I."xsd:string |
| http://purl.uniprot.org/citations/27133466 | http://purl.uniprot.org/core/author | "Kakegawa W."xsd:string |
| http://purl.uniprot.org/citations/27133466 | http://purl.uniprot.org/core/author | "Miura E."xsd:string |
| http://purl.uniprot.org/citations/27133466 | http://purl.uniprot.org/core/author | "Yuzaki M."xsd:string |
| http://purl.uniprot.org/citations/27133466 | http://purl.uniprot.org/core/author | "Aricescu A.R."xsd:string |
| http://purl.uniprot.org/citations/27133466 | http://purl.uniprot.org/core/author | "Kano M."xsd:string |
| http://purl.uniprot.org/citations/27133466 | http://purl.uniprot.org/core/author | "Sakimura K."xsd:string |
| http://purl.uniprot.org/citations/27133466 | http://purl.uniprot.org/core/author | "Mitakidis N."xsd:string |
| http://purl.uniprot.org/citations/27133466 | http://purl.uniprot.org/core/author | "Uchigashima M."xsd:string |
| http://purl.uniprot.org/citations/27133466 | http://purl.uniprot.org/core/author | "Budisantoso T."xsd:string |
| http://purl.uniprot.org/citations/27133466 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27133466 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/27133466 | http://purl.uniprot.org/core/pages | "752-767"xsd:string |
| http://purl.uniprot.org/citations/27133466 | http://purl.uniprot.org/core/title | "Transsynaptic Modulation of Kainate Receptor Functions by C1q-like Proteins."xsd:string |
| http://purl.uniprot.org/citations/27133466 | http://purl.uniprot.org/core/volume | "90"xsd:string |
| http://purl.uniprot.org/citations/27133466 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27133466 |