| http://purl.uniprot.org/citations/27135603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27135603 | http://www.w3.org/2000/01/rdf-schema#comment | "Signaling via the inducible costimulator ICOS fuels the stepwise development of follicular helper T cells (TFH cells). However, a signaling pathway unique to ICOS has not been identified. We found here that the kinase TBK1 associated with ICOS via a conserved motif, IProx, that shares homology with the tumor-necrosis-factor receptor (TNFR)-associated factors TRAF2 and TRAF3. Disruption of this motif abolished the association of TBK1 with ICOS, TRAF2 and TRAF3, which identified a TBK1-binding consensus. Alteration of this motif in ICOS or depletion of TBK1 in T cells severely impaired the differentiation of germinal center (GC) TFH cells and the development of GCs, interfered with B cell differentiation and disrupted the development of antibody responses, but the IProx motif and TBK1 were dispensable for the early differentiation of TFH cells. These results reveal a previously unknown ICOS-TBK1 signaling pathway that specifies the commitment of GC TFH cells."xsd:string |
| http://purl.uniprot.org/citations/27135603 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.3463"xsd:string |
| http://purl.uniprot.org/citations/27135603 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/27135603 | http://purl.uniprot.org/core/author | "Yates J.R."xsd:string |
| http://purl.uniprot.org/citations/27135603 | http://purl.uniprot.org/core/author | "Choi Y.S."xsd:string |
| http://purl.uniprot.org/citations/27135603 | http://purl.uniprot.org/core/author | "Kong K.F."xsd:string |
| http://purl.uniprot.org/citations/27135603 | http://purl.uniprot.org/core/author | "Altman A."xsd:string |
| http://purl.uniprot.org/citations/27135603 | http://purl.uniprot.org/core/author | "Crotty S."xsd:string |
| http://purl.uniprot.org/citations/27135603 | http://purl.uniprot.org/core/author | "Hu J.K."xsd:string |
| http://purl.uniprot.org/citations/27135603 | http://purl.uniprot.org/core/author | "Pedros C."xsd:string |
| http://purl.uniprot.org/citations/27135603 | http://purl.uniprot.org/core/author | "Canonigo-Balancio A.J."xsd:string |
| http://purl.uniprot.org/citations/27135603 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27135603 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/27135603 | http://purl.uniprot.org/core/pages | "825-833"xsd:string |
| http://purl.uniprot.org/citations/27135603 | http://purl.uniprot.org/core/title | "A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1."xsd:string |
| http://purl.uniprot.org/citations/27135603 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/27135603 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27135603 |
| http://purl.uniprot.org/citations/27135603 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27135603 |
| http://purl.uniprot.org/uniprot/#_A0A087WQM2-mappedCitation-27135603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27135603 |
| http://purl.uniprot.org/uniprot/#_D0E8G6-mappedCitation-27135603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27135603 |
| http://purl.uniprot.org/uniprot/#_A1L361-mappedCitation-27135603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27135603 |
| http://purl.uniprot.org/uniprot/#_A2A6A7-mappedCitation-27135603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27135603 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P835-mappedCitation-27135603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27135603 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P6W7-mappedCitation-27135603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27135603 |