| http://purl.uniprot.org/citations/27138253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27138253 | http://www.w3.org/2000/01/rdf-schema#comment | "Sorting and export of transmembrane cargoes and lysosomal hydrolases at the trans-Golgi network (TGN) are well understood. However, elucidation of the mechanism by which secretory cargoes are segregated for their release into the extracellular space remains a challenge. We have previously demonstrated that, in a reaction that requires Ca(2+), the soluble TGN-resident protein Cab45 is necessary for the sorting of secretory cargoes at the TGN. Here, we report that Cab45 reversibly assembles into oligomers in the presence of Ca(2+) These Cab45 oligomers specifically bind secretory proteins, such as COMP and LyzC, in a Ca(2+)-dependent manner in vitro. In intact cells, mutation of the Ca(2+)-binding sites in Cab45 impairs oligomerization, as well as COMP and LyzC sorting. Superresolution microscopy revealed that Cab45 colocalizes with secretory proteins and the TGN Ca(2+) pump (SPCA1) in specific TGN microdomains. These findings reveal that Ca(2+)-dependent changes in Cab45 mediate sorting of specific cargo molecules at the TGN."xsd:string |
| http://purl.uniprot.org/citations/27138253 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201601089"xsd:string |
| http://purl.uniprot.org/citations/27138253 | http://purl.uniprot.org/core/author | "Lamb D.C."xsd:string |
| http://purl.uniprot.org/citations/27138253 | http://purl.uniprot.org/core/author | "Habermann B."xsd:string |
| http://purl.uniprot.org/citations/27138253 | http://purl.uniprot.org/core/author | "Beck G."xsd:string |
| http://purl.uniprot.org/citations/27138253 | http://purl.uniprot.org/core/author | "von Blume J."xsd:string |
| http://purl.uniprot.org/citations/27138253 | http://purl.uniprot.org/core/author | "Leonhardt H."xsd:string |
| http://purl.uniprot.org/citations/27138253 | http://purl.uniprot.org/core/author | "Maiser A."xsd:string |
| http://purl.uniprot.org/citations/27138253 | http://purl.uniprot.org/core/author | "Crevenna A.H."xsd:string |
| http://purl.uniprot.org/citations/27138253 | http://purl.uniprot.org/core/author | "Pakdel M."xsd:string |
| http://purl.uniprot.org/citations/27138253 | http://purl.uniprot.org/core/author | "Blank B."xsd:string |
| http://purl.uniprot.org/citations/27138253 | http://purl.uniprot.org/core/author | "Kienzle C."xsd:string |
| http://purl.uniprot.org/citations/27138253 | http://purl.uniprot.org/core/author | "Bartnik K."xsd:string |
| http://purl.uniprot.org/citations/27138253 | http://purl.uniprot.org/core/author | "Emin D."xsd:string |
| http://purl.uniprot.org/citations/27138253 | http://purl.uniprot.org/core/author | "Prescher J."xsd:string |
| http://purl.uniprot.org/citations/27138253 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27138253 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/27138253 | http://purl.uniprot.org/core/pages | "305-314"xsd:string |
| http://purl.uniprot.org/citations/27138253 | http://purl.uniprot.org/core/title | "Secretory cargo sorting by Ca2+-dependent Cab45 oligomerization at the trans-Golgi network."xsd:string |
| http://purl.uniprot.org/citations/27138253 | http://purl.uniprot.org/core/volume | "213"xsd:string |
| http://purl.uniprot.org/citations/27138253 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27138253 |
| http://purl.uniprot.org/citations/27138253 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27138253 |
| http://purl.uniprot.org/uniprot/#_G3V1E2-mappedCitation-27138253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27138253 |
| http://purl.uniprot.org/uniprot/#_Q9BRK5-mappedCitation-27138253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27138253 |