| http://purl.uniprot.org/citations/27143361 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27143361 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27143361 | http://www.w3.org/2000/01/rdf-schema#comment | "Copper is an essential metal ion for embryonic development, iron acquisition, cardiac function, neuropeptide biogenesis, and other critical physiological processes. Ctr1 is a high affinity Cu(+) transporter on the plasma membrane and endosomes that exists as a full-length protein and a truncated form of Ctr1 lacking the methionine- and histidine-rich metal-binding ectodomain, and it exhibits reduced Cu(+) transport activity. Here, we identify the cathepsin L/B endolysosomal proteases functioning in a direct and rate-limiting step in the Ctr1 ectodomain cleavage. Cells and mice lacking cathepsin L accumulate full-length Ctr1 and hyper-accumulate copper. As Ctr1 also transports the chemotherapeutic drug cisplatin via direct binding to the ectodomain, we demonstrate that the combination of cisplatin with a cathepsin L/B inhibitor enhances cisplatin uptake and cell killing. These studies identify a new processing event and the key protease that cleaves the Ctr1 metal-binding ectodomain, which functions to regulate cellular Cu(+) and cisplatin acquisition."xsd:string |
| http://purl.uniprot.org/citations/27143361 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m116.731281"xsd:string |
| http://purl.uniprot.org/citations/27143361 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m116.731281"xsd:string |
| http://purl.uniprot.org/citations/27143361 | http://purl.uniprot.org/core/author | "Turk B."xsd:string |
| http://purl.uniprot.org/citations/27143361 | http://purl.uniprot.org/core/author | "Turk B."xsd:string |
| http://purl.uniprot.org/citations/27143361 | http://purl.uniprot.org/core/author | "Thiele D.J."xsd:string |
| http://purl.uniprot.org/citations/27143361 | http://purl.uniprot.org/core/author | "Thiele D.J."xsd:string |
| http://purl.uniprot.org/citations/27143361 | http://purl.uniprot.org/core/author | "Reinheckel T."xsd:string |
| http://purl.uniprot.org/citations/27143361 | http://purl.uniprot.org/core/author | "Reinheckel T."xsd:string |
| http://purl.uniprot.org/citations/27143361 | http://purl.uniprot.org/core/author | "Logeman B."xsd:string |
| http://purl.uniprot.org/citations/27143361 | http://purl.uniprot.org/core/author | "Logeman B."xsd:string |
| http://purl.uniprot.org/citations/27143361 | http://purl.uniprot.org/core/author | "Oehrvik H."xsd:string |
| http://purl.uniprot.org/citations/27143361 | http://purl.uniprot.org/core/author | "Oehrvik H."xsd:string |
| http://purl.uniprot.org/citations/27143361 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27143361 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27143361 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/27143361 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/27143361 | http://purl.uniprot.org/core/pages | "13905-13916"xsd:string |
| http://purl.uniprot.org/citations/27143361 | http://purl.uniprot.org/core/pages | "13905-13916"xsd:string |
| http://purl.uniprot.org/citations/27143361 | http://purl.uniprot.org/core/title | "Cathepsin Protease Controls Copper and Cisplatin Accumulation via Cleavage of the Ctr1 Metal-binding Ectodomain."xsd:string |
| http://purl.uniprot.org/citations/27143361 | http://purl.uniprot.org/core/title | "Cathepsin Protease Controls Copper and Cisplatin Accumulation via Cleavage of the Ctr1 Metal-binding Ectodomain."xsd:string |
| http://purl.uniprot.org/citations/27143361 | http://purl.uniprot.org/core/volume | "291"xsd:string |
| http://purl.uniprot.org/citations/27143361 | http://purl.uniprot.org/core/volume | "291"xsd:string |