| http://purl.uniprot.org/citations/27144356 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27144356 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27144356 | http://www.w3.org/2000/01/rdf-schema#comment | "ATP binding cassette (ABC) transporters play critical roles in maintaining sterol balance in higher eukaryotes. The ABCG5/ABCG8 heterodimer (G5G8) mediates excretion of neutral sterols in liver and intestines. Mutations disrupting G5G8 cause sitosterolaemia, a disorder characterized by sterol accumulation and premature atherosclerosis. Here we use crystallization in lipid bilayers to determine the X-ray structure of human G5G8 in a nucleotide-free state at 3.9 Å resolution, generating the first atomic model of an ABC sterol transporter. The structure reveals a new transmembrane fold that is present in a large and functionally diverse superfamily of ABC transporters. The transmembrane domains are coupled to the nucleotide-binding sites by networks of interactions that differ between the active and inactive ATPases, reflecting the catalytic asymmetry of the transporter. The G5G8 structure provides a mechanistic framework for understanding sterol transport and the disruptive effects of mutations causing sitosterolaemia."xsd:string |
| http://purl.uniprot.org/citations/27144356 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature17666"xsd:string |
| http://purl.uniprot.org/citations/27144356 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature17666"xsd:string |
| http://purl.uniprot.org/citations/27144356 | http://purl.uniprot.org/core/author | "Grishin N.V."xsd:string |
| http://purl.uniprot.org/citations/27144356 | http://purl.uniprot.org/core/author | "Grishin N.V."xsd:string |
| http://purl.uniprot.org/citations/27144356 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/27144356 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/27144356 | http://purl.uniprot.org/core/author | "Wang J.'"xsd:string |
| http://purl.uniprot.org/citations/27144356 | http://purl.uniprot.org/core/author | "Wang J.'"xsd:string |
| http://purl.uniprot.org/citations/27144356 | http://purl.uniprot.org/core/author | "Lee J.Y."xsd:string |
| http://purl.uniprot.org/citations/27144356 | http://purl.uniprot.org/core/author | "Lee J.Y."xsd:string |
| http://purl.uniprot.org/citations/27144356 | http://purl.uniprot.org/core/author | "Kinch L.N."xsd:string |
| http://purl.uniprot.org/citations/27144356 | http://purl.uniprot.org/core/author | "Kinch L.N."xsd:string |
| http://purl.uniprot.org/citations/27144356 | http://purl.uniprot.org/core/author | "Cohen J.C."xsd:string |
| http://purl.uniprot.org/citations/27144356 | http://purl.uniprot.org/core/author | "Cohen J.C."xsd:string |
| http://purl.uniprot.org/citations/27144356 | http://purl.uniprot.org/core/author | "Hobbs H.H."xsd:string |
| http://purl.uniprot.org/citations/27144356 | http://purl.uniprot.org/core/author | "Hobbs H.H."xsd:string |
| http://purl.uniprot.org/citations/27144356 | http://purl.uniprot.org/core/author | "Borek D.M."xsd:string |
| http://purl.uniprot.org/citations/27144356 | http://purl.uniprot.org/core/author | "Borek D.M."xsd:string |
| http://purl.uniprot.org/citations/27144356 | http://purl.uniprot.org/core/author | "Otwinowski Z."xsd:string |
| http://purl.uniprot.org/citations/27144356 | http://purl.uniprot.org/core/author | "Otwinowski Z."xsd:string |
| http://purl.uniprot.org/citations/27144356 | http://purl.uniprot.org/core/author | "Rosenbaum D.M."xsd:string |
| http://purl.uniprot.org/citations/27144356 | http://purl.uniprot.org/core/author | "Rosenbaum D.M."xsd:string |