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http://purl.uniprot.org/citations/27144979http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Background

5-Hydroxytryptamine (5-HT) 3 receptor plays a crucial role in craving of alcohol dependence. Recent evidence shows that chronic alcohol exposure causes changes in gene expression and induces behavioral changes. However, the relationship between gene expression of 5-HT3 receptor and craving in alcohol-dependent patients is not fully understood.

Objectives

The aim of this preliminary study was to investigate the relationship between gene expression of the 5-HT3 receptor and craving in alcohol-dependent patients and the epigenetic mechanism.

Methods

We recruited 50 male Han Chinese alcohol-dependent patients and 46 male Han Chinese healthy controls. We investigated the changes of HTR3A mRNA, which encodes the 5-HT3 receptor A subunit, and H3K9 acetylation in HTR3A promoter region. Obsessive Compulsive Drinking Scale (OCDS) was used to assess the craving of alcohol-dependent patients relative to controls.

Results

HTR3A mRNA expression levels and acetylation levels of H3K9 in the HTR3A promoter region were significantly higher in the alcohol-dependent patients. HTR3A mRNA expression levels were positively correlated with OCDS scores. Moreover, HTR3A mRNA expression levels were positively correlated with acetylation levels of H3K9 in HTR3A promoter region.

Conclusion

The current findings suggest that HTR3A mRNA expression levels were positively correlated with craving in Han Chinese alcohol-dependent patients. The regulation of H3K9 histone acetylation in HTR3A promoter region may offer a target for the treatment of alcohol dependence."xsd:string
http://purl.uniprot.org/citations/27144979http://purl.org/dc/terms/identifier"doi:10.3109/00952990.2016.1160098"xsd:string
http://purl.uniprot.org/citations/27144979http://purl.uniprot.org/core/author"Lu L."xsd:string
http://purl.uniprot.org/citations/27144979http://purl.uniprot.org/core/author"Shi L."xsd:string
http://purl.uniprot.org/citations/27144979http://purl.uniprot.org/core/author"Wang L.L."xsd:string
http://purl.uniprot.org/citations/27144979http://purl.uniprot.org/core/author"Hao W."xsd:string
http://purl.uniprot.org/citations/27144979http://purl.uniprot.org/core/author"Xu Y.H."xsd:string
http://purl.uniprot.org/citations/27144979http://purl.uniprot.org/core/author"Miao Q."xsd:string
http://purl.uniprot.org/citations/27144979http://purl.uniprot.org/core/author"Zhang R.L."xsd:string
http://purl.uniprot.org/citations/27144979http://purl.uniprot.org/core/author"Liu T.Q."xsd:string
http://purl.uniprot.org/citations/27144979http://purl.uniprot.org/core/author"Lei J.P."xsd:string
http://purl.uniprot.org/citations/27144979http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/27144979http://purl.uniprot.org/core/name"Am J Drug Alcohol Abuse"xsd:string
http://purl.uniprot.org/citations/27144979http://purl.uniprot.org/core/pages"316-324"xsd:string
http://purl.uniprot.org/citations/27144979http://purl.uniprot.org/core/title"The association of HTR3A mRNA expression and craving in Han Chinese alcohol-dependent patients: a preliminary study."xsd:string
http://purl.uniprot.org/citations/27144979http://purl.uniprot.org/core/volume"42"xsd:string
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