| http://purl.uniprot.org/citations/27146110 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27146110 | http://www.w3.org/2000/01/rdf-schema#comment | "Kinesin-8 motor proteins destabilize microtubules. Their absence during cell division is associated with disorganized mitotic chromosome movements and chromosome loss. Despite recent work studying effects of kinesin-8s on microtubule dynamics, it remains unclear whether the kinesin-8 mitotic phenotypes are consequences of their effect on microtubule dynamics, their well-established motor activity, or additional, unknown functions. To better understand the role of kinesin-8 proteins in mitosis, we studied the effects of deletion of the fission yeast kinesin-8 proteins Klp5 and Klp6 on chromosome movements and spindle length dynamics. Aberrant microtubule-driven kinetochore pushing movements and tripolar mitotic spindles occurred in cells lacking Klp5 but not Klp6. Kinesin-8-deletion strains showed large fluctuations in metaphase spindle length, suggesting a disruption of spindle length stabilization. Comparison of our results from light microscopy with a mathematical model suggests that kinesin-8-induced effects on microtubule dynamics, kinetochore attachment stability, and sliding force in the spindle can explain the aberrant chromosome movements and spindle length fluctuations seen."xsd:string |
| http://purl.uniprot.org/citations/27146110 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e15-07-0505"xsd:string |
| http://purl.uniprot.org/citations/27146110 | http://purl.uniprot.org/core/author | "McIntosh J.R."xsd:string |
| http://purl.uniprot.org/citations/27146110 | http://purl.uniprot.org/core/author | "Betterton M.D."xsd:string |
| http://purl.uniprot.org/citations/27146110 | http://purl.uniprot.org/core/author | "Hough L.E."xsd:string |
| http://purl.uniprot.org/citations/27146110 | http://purl.uniprot.org/core/author | "Crapo A."xsd:string |
| http://purl.uniprot.org/citations/27146110 | http://purl.uniprot.org/core/author | "Gergely Z.R."xsd:string |
| http://purl.uniprot.org/citations/27146110 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27146110 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/27146110 | http://purl.uniprot.org/core/pages | "3490-3514"xsd:string |
| http://purl.uniprot.org/citations/27146110 | http://purl.uniprot.org/core/title | "Kinesin-8 effects on mitotic microtubule dynamics contribute to spindle function in fission yeast."xsd:string |
| http://purl.uniprot.org/citations/27146110 | http://purl.uniprot.org/core/volume | "27"xsd:string |
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| http://purl.uniprot.org/uniprot/O59751#attribution-C9CB7ABB80486C919C582482F3CC1BCE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/27146110 |
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| http://purl.uniprot.org/uniprot/O59751 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27146110 |
| http://purl.uniprot.org/uniprot/P05219 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27146110 |