| http://purl.uniprot.org/citations/27146149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27146149 | http://www.w3.org/2000/01/rdf-schema#comment | "Activation of β-catenin-dependent canonical Wnt signaling in endothelial cells plays a key role in angiogenesis during development and ischemic diseases, however, other roles of Wnt/β-catenin signaling in endothelial cells remain poorly understood. Here, we report that sustained activation of β-catenin signaling in endothelial cells causes cardiac dysfunction through suppressing neuregulin-ErbB pathway in the heart. Conditional gain-of-function mutation of β-catenin, which activates Wnt/β-catenin signaling in Bmx-positive arterial endothelial cells (Bmx/CA mice) led to progressive cardiac dysfunction and 100% mortality at 40 weeks after tamoxifen treatment. Electron microscopic analysis revealed dilatation of T-tubules and degeneration of mitochondria in cardiomyocytes of Bmx/CA mice, which are similar to the changes observed in mice with decreased neuregulin-ErbB signaling. Endothelial expression of Nrg1 and cardiac ErbB signaling were suppressed in Bmx/CA mice. The cardiac dysfunction of Bmx/CA mice was ameliorated by administration of recombinant neuregulin protein. These results collectively suggest that sustained activation of Wnt/β-catenin signaling in endothelial cells might be a cause of heart failure through suppressing neuregulin-ErbB signaling, and that the Wnt/β-catenin/NRG axis in cardiac endothelial cells might become a therapeutic target for heart failure."xsd:string |
| http://purl.uniprot.org/citations/27146149 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep25009"xsd:string |
| http://purl.uniprot.org/citations/27146149 | http://purl.uniprot.org/core/author | "Harada M."xsd:string |
| http://purl.uniprot.org/citations/27146149 | http://purl.uniprot.org/core/author | "Nakagawa A."xsd:string |
| http://purl.uniprot.org/citations/27146149 | http://purl.uniprot.org/core/author | "Okada K."xsd:string |
| http://purl.uniprot.org/citations/27146149 | http://purl.uniprot.org/core/author | "Nomura S."xsd:string |
| http://purl.uniprot.org/citations/27146149 | http://purl.uniprot.org/core/author | "Ueda K."xsd:string |
| http://purl.uniprot.org/citations/27146149 | http://purl.uniprot.org/core/author | "Sakai T."xsd:string |
| http://purl.uniprot.org/citations/27146149 | http://purl.uniprot.org/core/author | "Lee J.K."xsd:string |
| http://purl.uniprot.org/citations/27146149 | http://purl.uniprot.org/core/author | "Hashimoto A."xsd:string |
| http://purl.uniprot.org/citations/27146149 | http://purl.uniprot.org/core/author | "Sumida T."xsd:string |
| http://purl.uniprot.org/citations/27146149 | http://purl.uniprot.org/core/author | "Oka T."xsd:string |
| http://purl.uniprot.org/citations/27146149 | http://purl.uniprot.org/core/author | "Noda T."xsd:string |
| http://purl.uniprot.org/citations/27146149 | http://purl.uniprot.org/core/author | "Akazawa H."xsd:string |
| http://purl.uniprot.org/citations/27146149 | http://purl.uniprot.org/core/author | "Komuro I."xsd:string |
| http://purl.uniprot.org/citations/27146149 | http://purl.uniprot.org/core/author | "Sakata Y."xsd:string |
| http://purl.uniprot.org/citations/27146149 | http://purl.uniprot.org/core/author | "Kuramoto Y."xsd:string |
| http://purl.uniprot.org/citations/27146149 | http://purl.uniprot.org/core/author | "Higo T."xsd:string |
| http://purl.uniprot.org/citations/27146149 | http://purl.uniprot.org/core/author | "Adams R.H."xsd:string |
| http://purl.uniprot.org/citations/27146149 | http://purl.uniprot.org/core/author | "Limbourg F.P."xsd:string |
| http://purl.uniprot.org/citations/27146149 | http://purl.uniprot.org/core/author | "Shiojima I."xsd:string |
| http://purl.uniprot.org/citations/27146149 | http://purl.uniprot.org/core/author | "Naito A.T."xsd:string |
| http://purl.uniprot.org/citations/27146149 | http://purl.uniprot.org/core/author | "Shibamoto M."xsd:string |
| http://purl.uniprot.org/citations/27146149 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |