| http://purl.uniprot.org/citations/27150059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27150059 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent studies indicate that a high level of nesfatin-1/Nucleobindin-2 (NUCB-2) is associated with poor outcome and promotes cell migration in breast cancer and prostate cancer. However, the role of NUCB2 is not well known in colon cancer. In this study, NUCB-2 level in colon cancer tissue was higher than that in non-tumor tissue. Suppression of NUCB-2 in a colon cancer cell line SW620 inhibited migration and invasion. The microarray analysis showed that low expression level of transcription factor ZEB1 in NUCB-2 knockdowned SW620 cells. In addition, expression level of epithelial-mesenchymal transition (EMT)-related molecules including N-cadherin, E-cadherin, β-catenin, Slug and Twist was affected by NUCB-2 suppression and ZEB1-denepdent pathway. The signaling pathway liver kinase B1(LKB1)/AMP-dependent protein kinase (AMPK)/target of rapamycin complex (TORC) 1 was involved in regulation of NUCB-2-mediated metastasis and EMT properties. Suppression of NUCB-2 inhibited tumor nodules formation in a murine colon tumor model as well. In summary, nesfatin-1/NUCB-2 enhanced migration, invasion and EMT in colon cancer cells through LKB1/AMPK/TORC1/ZEB1 pathways in vitro and in vivo."xsd:string |
| http://purl.uniprot.org/citations/27150059 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.9140"xsd:string |
| http://purl.uniprot.org/citations/27150059 | http://purl.uniprot.org/core/author | "Wang J.Y."xsd:string |
| http://purl.uniprot.org/citations/27150059 | http://purl.uniprot.org/core/author | "Kuo P.L."xsd:string |
| http://purl.uniprot.org/citations/27150059 | http://purl.uniprot.org/core/author | "Wu D.C."xsd:string |
| http://purl.uniprot.org/citations/27150059 | http://purl.uniprot.org/core/author | "Chiu Y.J."xsd:string |
| http://purl.uniprot.org/citations/27150059 | http://purl.uniprot.org/core/author | "Ho Y.W."xsd:string |
| http://purl.uniprot.org/citations/27150059 | http://purl.uniprot.org/core/author | "Yen M.C."xsd:string |
| http://purl.uniprot.org/citations/27150059 | http://purl.uniprot.org/core/author | "Kan J.Y."xsd:string |
| http://purl.uniprot.org/citations/27150059 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27150059 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/27150059 | http://purl.uniprot.org/core/pages | "31336-31349"xsd:string |
| http://purl.uniprot.org/citations/27150059 | http://purl.uniprot.org/core/title | "Nesfatin-1/Nucleobindin-2 enhances cell migration, invasion, and epithelial-mesenchymal transition via LKB1/AMPK/TORC1/ZEB1 pathways in colon cancer."xsd:string |
| http://purl.uniprot.org/citations/27150059 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/27150059 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27150059 |
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