| http://purl.uniprot.org/citations/27151979 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27151979 | http://www.w3.org/2000/01/rdf-schema#comment | "Polycomb group (PcG) protein complexes repress transcription by modifying target gene chromatin. In Drosophila, this repression requires association of PcG protein complexes with cis-regulatory Polycomb response elements (PREs), but the interactions permitting formation of these assemblies are poorly understood. We show that the Sfmbt subunit of the DNA-binding Pho-repressive complex (PhoRC) and the Scm subunit of the canonical Polycomb-repressive complex 1 (PRC1) directly bind each other through their SAM domains. The 1.9 Å crystal structure of the Scm-SAM:Sfmbt-SAM complex reveals the recognition mechanism and shows that Sfmbt-SAM lacks the polymerization capacity of the SAM domains of Scm and its PRC1 partner subunit, Ph. Functional analyses in Drosophila demonstrate that Sfmbt-SAM and Scm-SAM are essential for repression and that PhoRC DNA binding is critical to initiate PRC1 association with PREs. Together, this suggests that PRE-tethered Sfmbt-SAM nucleates PRC1 recruitment and that Scm-SAM/Ph-SAM-mediated polymerization then results in the formation of PRC1-compacted chromatin."xsd:string |
| http://purl.uniprot.org/citations/27151979 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.279141.116"xsd:string |
| http://purl.uniprot.org/citations/27151979 | http://purl.uniprot.org/core/author | "Mann M."xsd:string |
| http://purl.uniprot.org/citations/27151979 | http://purl.uniprot.org/core/author | "Muller J."xsd:string |
| http://purl.uniprot.org/citations/27151979 | http://purl.uniprot.org/core/author | "Benda C."xsd:string |
| http://purl.uniprot.org/citations/27151979 | http://purl.uniprot.org/core/author | "Sheahan T."xsd:string |
| http://purl.uniprot.org/citations/27151979 | http://purl.uniprot.org/core/author | "Frey F."xsd:string |
| http://purl.uniprot.org/citations/27151979 | http://purl.uniprot.org/core/author | "Stoehr G."xsd:string |
| http://purl.uniprot.org/citations/27151979 | http://purl.uniprot.org/core/author | "Finkl K."xsd:string |
| http://purl.uniprot.org/citations/27151979 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27151979 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/27151979 | http://purl.uniprot.org/core/pages | "1116-1127"xsd:string |
| http://purl.uniprot.org/citations/27151979 | http://purl.uniprot.org/core/title | "Molecular basis of PRC1 targeting to Polycomb response elements by PhoRC."xsd:string |
| http://purl.uniprot.org/citations/27151979 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/27151979 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27151979 |
| http://purl.uniprot.org/citations/27151979 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27151979 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KEM5-mappedCitation-27151979 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27151979 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K6M7-mappedCitation-27151979 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27151979 |
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| http://purl.uniprot.org/uniprot/#_A2NUB8-mappedCitation-27151979 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27151979 |
| http://purl.uniprot.org/uniprot/#_A0A126GUV3-mappedCitation-27151979 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27151979 |
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| http://purl.uniprot.org/uniprot/#_A4V304-mappedCitation-27151979 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27151979 |