| http://purl.uniprot.org/citations/27156450 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27156450 | http://www.w3.org/2000/01/rdf-schema#comment | "Telomerase is the ribonucleoprotein enzyme that replenishes telomeric DNA and maintains genome integrity. Minimally, telomerase activity requires a templating RNA and a catalytic protein. Additional proteins are required for activity on telomeres in vivo. Here, we report that the Pop1, Pop6, and Pop7 proteins, known components of RNase P and RNase MRP, bind to yeast telomerase RNA and are essential constituents of the telomerase holoenzyme. Pop1/Pop6/Pop7 binding is specific and involves an RNA domain highly similar to a protein-binding domain in the RNAs of RNase P/MRP. The results also show that Pop1/Pop6/Pop7 function to maintain the essential components Est1 and Est2 on the RNA in vivo. Consistently, addition of Pop1 allows for telomerase activity reconstitution with wild-type telomerase RNA in vitro. Thus, the same chaperoning module has allowed the evolution of functionally and, remarkably, structurally distinct RNPs, telomerase, and RNases P/MRP from unrelated progenitor RNAs."xsd:string |
| http://purl.uniprot.org/citations/27156450 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2016.04.018"xsd:string |
| http://purl.uniprot.org/citations/27156450 | http://purl.uniprot.org/core/author | "Wellinger R.J."xsd:string |
| http://purl.uniprot.org/citations/27156450 | http://purl.uniprot.org/core/author | "Lemieux B."xsd:string |
| http://purl.uniprot.org/citations/27156450 | http://purl.uniprot.org/core/author | "Perederina A."xsd:string |
| http://purl.uniprot.org/citations/27156450 | http://purl.uniprot.org/core/author | "Krasilnikov A.S."xsd:string |
| http://purl.uniprot.org/citations/27156450 | http://purl.uniprot.org/core/author | "Dubois M.L."xsd:string |
| http://purl.uniprot.org/citations/27156450 | http://purl.uniprot.org/core/author | "Laterreur N."xsd:string |
| http://purl.uniprot.org/citations/27156450 | http://purl.uniprot.org/core/author | "Noel J.F."xsd:string |
| http://purl.uniprot.org/citations/27156450 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27156450 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/27156450 | http://purl.uniprot.org/core/pages | "1171-1181"xsd:string |
| http://purl.uniprot.org/citations/27156450 | http://purl.uniprot.org/core/title | "Active Yeast Telomerase Shares Subunits with Ribonucleoproteins RNase P and RNase MRP."xsd:string |
| http://purl.uniprot.org/citations/27156450 | http://purl.uniprot.org/core/volume | "165"xsd:string |
| http://purl.uniprot.org/citations/27156450 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27156450 |
| http://purl.uniprot.org/citations/27156450 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27156450 |
| http://purl.uniprot.org/uniprot/P38291#attribution-F4BB41E7BD2749F4BEF237F075EFC22A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/27156450 |
| http://purl.uniprot.org/uniprot/P53218#attribution-F4BB41E7BD2749F4BEF237F075EFC22A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/27156450 |
| http://purl.uniprot.org/uniprot/P41812#attribution-F4BB41E7BD2749F4BEF237F075EFC22A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/27156450 |
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| http://purl.uniprot.org/uniprot/#_A0A8H4BXP7-mappedCitation-27156450 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27156450 |
| http://purl.uniprot.org/uniprot/#_P41812-mappedCitation-27156450 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27156450 |
| http://purl.uniprot.org/uniprot/#_P38291-mappedCitation-27156450 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27156450 |
| http://purl.uniprot.org/uniprot/#_P17214-mappedCitation-27156450 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27156450 |