| http://purl.uniprot.org/citations/27157137 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27157137 | http://www.w3.org/2000/01/rdf-schema#comment | "In mammalian post-transcriptional gene silencing, the Argonaute protein AGO2 indirectly recruits translation inhibitors, deadenylase complexes, and decapping factors to microRNA-targeted mRNAs, thereby repressing mRNA translation and accelerating mRNA decay. However, the exact composition and assembly pathway of the microRNA-induced silencing complex are not completely elucidated. As the GYF domain of human GIGYF2 was shown to bind AGO2 in pulldown experiments, we wondered whether GIGYF2 could be a novel protein component of the microRNA-induced silencing complex. Here we show that full-length GIGYF2 coimmunoprecipitates with AGO2 in human cells, and demonstrate that, upon tethering to a reporter mRNA, GIGYF2 exhibits strong, dose-dependent silencing activity, involving both mRNA destabilization and translational repression."xsd:string |
| http://purl.uniprot.org/citations/27157137 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2016.05.022"xsd:string |
| http://purl.uniprot.org/citations/27157137 | http://purl.uniprot.org/core/author | "Chen H."xsd:string |
| http://purl.uniprot.org/citations/27157137 | http://purl.uniprot.org/core/author | "Liang F."xsd:string |
| http://purl.uniprot.org/citations/27157137 | http://purl.uniprot.org/core/author | "Dautry F."xsd:string |
| http://purl.uniprot.org/citations/27157137 | http://purl.uniprot.org/core/author | "Kryszke M.H."xsd:string |
| http://purl.uniprot.org/citations/27157137 | http://purl.uniprot.org/core/author | "Adjeriou B."xsd:string |
| http://purl.uniprot.org/citations/27157137 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27157137 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/27157137 | http://purl.uniprot.org/core/pages | "289-294"xsd:string |
| http://purl.uniprot.org/citations/27157137 | http://purl.uniprot.org/core/title | "Post-transcriptional gene silencing activity of human GIGYF2."xsd:string |
| http://purl.uniprot.org/citations/27157137 | http://purl.uniprot.org/core/volume | "475"xsd:string |
| http://purl.uniprot.org/citations/27157137 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27157137 |
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| http://purl.uniprot.org/uniprot/#_B4DRT8-mappedCitation-27157137 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27157137 |
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