| http://purl.uniprot.org/citations/27159239 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27159239 | http://www.w3.org/2000/01/rdf-schema#comment | "The spindle position checkpoint (SPOC) is a spindle pole body (SPB, equivalent of mammalian centrosome) associated surveillance mechanism that halts mitotic exit upon spindle mis-orientation. Here, we monitored the interaction between SPB proteins and the SPOC component Bfa1 by FRET microscopy. We show that Bfa1 binds to the scaffold-protein Nud1 and the γ-tubulin receptor Spc72. Spindle misalignment specifically disrupts Bfa1-Spc72 interaction by a mechanism that requires the 14-3-3-family protein Bmh1 and the MARK/PAR-kinase Kin4. Dissociation of Bfa1 from Spc72 prevents the inhibitory phosphorylation of Bfa1 by the polo-like kinase Cdc5. We propose Spc72 as a regulatory hub that coordinates the activity of Kin4 and Cdc5 towards Bfa1. In addition, analysis of spc72∆ cells shows that a mitotic-exit-promoting dominant signal, which is triggered upon elongation of the spindle into the bud, overrides the SPOC. Our data reinforce the importance of daughter-cell-associated factors and centrosome-based regulations in mitotic exit and SPOC control."xsd:string |
| http://purl.uniprot.org/citations/27159239 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.14029"xsd:string |
| http://purl.uniprot.org/citations/27159239 | http://purl.uniprot.org/core/author | "Sourjik V."xsd:string |
| http://purl.uniprot.org/citations/27159239 | http://purl.uniprot.org/core/author | "Pereira G."xsd:string |
| http://purl.uniprot.org/citations/27159239 | http://purl.uniprot.org/core/author | "Malengo G."xsd:string |
| http://purl.uniprot.org/citations/27159239 | http://purl.uniprot.org/core/author | "Gryaznova Y."xsd:string |
| http://purl.uniprot.org/citations/27159239 | http://purl.uniprot.org/core/author | "Koca Caydasi A."xsd:string |
| http://purl.uniprot.org/citations/27159239 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27159239 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/27159239 | http://purl.uniprot.org/core/pages | "e14029"xsd:string |
| http://purl.uniprot.org/citations/27159239 | http://purl.uniprot.org/core/title | "A FRET-based study reveals site-specific regulation of spindle position checkpoint proteins at yeast centrosomes."xsd:string |
| http://purl.uniprot.org/citations/27159239 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/27159239 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27159239 |
| http://purl.uniprot.org/citations/27159239 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27159239 |
| http://purl.uniprot.org/uniprot/#_P39723-mappedCitation-27159239 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27159239 |
| http://purl.uniprot.org/uniprot/#_Q01919-mappedCitation-27159239 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27159239 |
| http://purl.uniprot.org/uniprot/#_P32336-mappedCitation-27159239 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27159239 |
| http://purl.uniprot.org/uniprot/#_P47113-mappedCitation-27159239 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27159239 |
| http://purl.uniprot.org/uniprot/#_P29311-mappedCitation-27159239 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27159239 |
| http://purl.uniprot.org/uniprot/#_P32562-mappedCitation-27159239 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27159239 |
| http://purl.uniprot.org/uniprot/P39723 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27159239 |
| http://purl.uniprot.org/uniprot/P32562 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27159239 |
| http://purl.uniprot.org/uniprot/P47113 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27159239 |
| http://purl.uniprot.org/uniprot/P29311 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27159239 |