| http://purl.uniprot.org/citations/27159452 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27159452 | http://www.w3.org/2000/01/rdf-schema#comment | "Internal ribosome entry sites (IRESs) mediate cap-independent translation of viral mRNAs. Using electron cryo-microscopy of a single specimen, we present five ribosome structures formed with the Taura syndrome virus IRES and translocase eEF2•GTP bound with sordarin. The structures suggest a trajectory of IRES translocation, required for translation initiation, and provide an unprecedented view of eEF2 dynamics. The IRES rearranges from extended to bent to extended conformations. This inchworm-like movement is coupled with ribosomal inter-subunit rotation and 40S head swivel. eEF2, attached to the 60S subunit, slides along the rotating 40S subunit to enter the A site. Its diphthamide-bearing tip at domain IV separates the tRNA-mRNA-like pseudoknot I (PKI) of the IRES from the decoding center. This unlocks 40S domains, facilitating head swivel and biasing IRES translocation via hitherto-elusive intermediates with PKI captured between the A and P sites. The structures suggest missing links in our understanding of tRNA translocation."xsd:string |
| http://purl.uniprot.org/citations/27159452 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.14874"xsd:string |
| http://purl.uniprot.org/citations/27159452 | http://purl.uniprot.org/core/author | "Grigorieff N."xsd:string |
| http://purl.uniprot.org/citations/27159452 | http://purl.uniprot.org/core/author | "Grant T."xsd:string |
| http://purl.uniprot.org/citations/27159452 | http://purl.uniprot.org/core/author | "Koh C.S."xsd:string |
| http://purl.uniprot.org/citations/27159452 | http://purl.uniprot.org/core/author | "Korostelev A.A."xsd:string |
| http://purl.uniprot.org/citations/27159452 | http://purl.uniprot.org/core/author | "Abeyrathne P.D."xsd:string |
| http://purl.uniprot.org/citations/27159452 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27159452 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/27159452 | http://purl.uniprot.org/core/pages | "e14874"xsd:string |
| http://purl.uniprot.org/citations/27159452 | http://purl.uniprot.org/core/title | "Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome."xsd:string |
| http://purl.uniprot.org/citations/27159452 | http://purl.uniprot.org/core/volume | "5"xsd:string |
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