| http://purl.uniprot.org/citations/27160050 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27160050 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27160050 | http://www.w3.org/2000/01/rdf-schema#comment | "Continuous cycles of nucleocytoplasmic transport require disassembly of transport receptor/Ran-GTP complexes in the cytoplasm. A basic disassembly mechanism in all eukaryotes depends on soluble RanGAP and RanBP1. In vertebrates, a significant fraction of RanGAP1 stably interacts with the nucleoporin RanBP2 at a binding site that is flanked by FG-repeats and Ran-binding domains, and overlaps with RanBP2's SUMO E3 ligase region. Here, we show that the RanBP2/RanGAP1*SUMO1/Ubc9 complex functions as an autonomous disassembly machine with a preference for the export receptor Crm1. We describe three in vitro reconstituted disassembly intermediates, which show binding of a Crm1 export complex via two FG-repeat patches, cargo-release by RanBP2's Ran-binding domains and retention of free Crm1 at RanBP2 after Ran-GTP hydrolysis. Intriguingly, all intermediates are compatible with SUMO E3 ligase activity, suggesting that the RanBP2/RanGAP1*SUMO1/Ubc9 complex may link Crm1- and SUMO-dependent functions."xsd:string |
| http://purl.uniprot.org/citations/27160050 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms11482"xsd:string |
| http://purl.uniprot.org/citations/27160050 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms11482"xsd:string |
| http://purl.uniprot.org/citations/27160050 | http://purl.uniprot.org/core/author | "Melchior F."xsd:string |
| http://purl.uniprot.org/citations/27160050 | http://purl.uniprot.org/core/author | "Melchior F."xsd:string |
| http://purl.uniprot.org/citations/27160050 | http://purl.uniprot.org/core/author | "Flotho A."xsd:string |
| http://purl.uniprot.org/citations/27160050 | http://purl.uniprot.org/core/author | "Flotho A."xsd:string |
| http://purl.uniprot.org/citations/27160050 | http://purl.uniprot.org/core/author | "Hofhaus G."xsd:string |
| http://purl.uniprot.org/citations/27160050 | http://purl.uniprot.org/core/author | "Hofhaus G."xsd:string |
| http://purl.uniprot.org/citations/27160050 | http://purl.uniprot.org/core/author | "Das H."xsd:string |
| http://purl.uniprot.org/citations/27160050 | http://purl.uniprot.org/core/author | "Das H."xsd:string |
| http://purl.uniprot.org/citations/27160050 | http://purl.uniprot.org/core/author | "Ritterhoff T."xsd:string |
| http://purl.uniprot.org/citations/27160050 | http://purl.uniprot.org/core/author | "Ritterhoff T."xsd:string |
| http://purl.uniprot.org/citations/27160050 | http://purl.uniprot.org/core/author | "Schroeder R.R."xsd:string |
| http://purl.uniprot.org/citations/27160050 | http://purl.uniprot.org/core/author | "Schroeder R.R."xsd:string |
| http://purl.uniprot.org/citations/27160050 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27160050 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27160050 | http://purl.uniprot.org/core/name | "Nat. Commun."xsd:string |
| http://purl.uniprot.org/citations/27160050 | http://purl.uniprot.org/core/name | "Nat. Commun."xsd:string |
| http://purl.uniprot.org/citations/27160050 | http://purl.uniprot.org/core/pages | "11482"xsd:string |
| http://purl.uniprot.org/citations/27160050 | http://purl.uniprot.org/core/pages | "11482"xsd:string |
| http://purl.uniprot.org/citations/27160050 | http://purl.uniprot.org/core/title | "The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes."xsd:string |
| http://purl.uniprot.org/citations/27160050 | http://purl.uniprot.org/core/title | "The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes."xsd:string |