| http://purl.uniprot.org/citations/27167339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27167339 | http://www.w3.org/2000/01/rdf-schema#comment | "Vascular endothelial growth factor receptor-1/fms-related tyrosine kinase-1 (VEGFR-1/Flt-1) is a tyrosine kinase receptor that binds placental growth factor (PlGF). Flt-1 is also highly expressed in breast-cancer tissues and breast-cancer cell lines. However, the molecular mechanism by which Flt-1 promotes breast-cancer invasion and metastasis by binding to PlGF-1 is unclear. In this study, we discovered that PlGF-1 and Flt-1 played a key role in the migration and invasion of breast cancer. Flt-1 promoted the migration and chemotaxis of breast-cancer cells by binding to PlGF-1. In addition, Flt-1 was confirmed to be a direct target gene of miR-507. miR-507 up-regulation inhibited the invasion and metastasis of breast-cancer cells in vitro and in vivo. Flt-1 overexpression rescued the invasion partially caused by the ectopic expression of miR-507. miR-507 expression in breast-cancer tissues and cell lines was lower than that in adjacent non-neoplastic tissues and normal cells. Clinical analysis indicated that miR-507 was negatively correlated with tumor differentiation, lymphatic metastasis, and the expression of Flt-1 in breast cancer. Furthermore, we showed that miR-507 down-regulation was due to the hypermethylation of its promotor region. Our results indicated that miR-507 represented potential therapeutic targets in breast cancer by modulating Flt-1."xsd:string |
| http://purl.uniprot.org/citations/27167339 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.9163"xsd:string |
| http://purl.uniprot.org/citations/27167339 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/27167339 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/27167339 | http://purl.uniprot.org/core/author | "Yin C."xsd:string |
| http://purl.uniprot.org/citations/27167339 | http://purl.uniprot.org/core/author | "Jia L."xsd:string |
| http://purl.uniprot.org/citations/27167339 | http://purl.uniprot.org/core/author | "Cao B."xsd:string |
| http://purl.uniprot.org/citations/27167339 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27167339 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/27167339 | http://purl.uniprot.org/core/pages | "36743-36754"xsd:string |
| http://purl.uniprot.org/citations/27167339 | http://purl.uniprot.org/core/title | "MiR-507 inhibits the migration and invasion of human breastcancer cells through Flt-1 suppression."xsd:string |
| http://purl.uniprot.org/citations/27167339 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/27167339 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27167339 |
| http://purl.uniprot.org/citations/27167339 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27167339 |
| http://purl.uniprot.org/uniprot/#_H9N1E7-mappedCitation-27167339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27167339 |
| http://purl.uniprot.org/uniprot/#_H9N1E8-mappedCitation-27167339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27167339 |
| http://purl.uniprot.org/uniprot/#_B5A924-mappedCitation-27167339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27167339 |
| http://purl.uniprot.org/uniprot/#_B1AC84-mappedCitation-27167339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27167339 |
| http://purl.uniprot.org/uniprot/#_P17948-mappedCitation-27167339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27167339 |
| http://purl.uniprot.org/uniprot/#_L7RSL3-mappedCitation-27167339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27167339 |
| http://purl.uniprot.org/uniprot/#_Q16332-mappedCitation-27167339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27167339 |
| http://purl.uniprot.org/uniprot/#_Q16333-mappedCitation-27167339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27167339 |
| http://purl.uniprot.org/uniprot/#_Q59GQ9-mappedCitation-27167339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27167339 |
| http://purl.uniprot.org/uniprot/#_S5TRK2-mappedCitation-27167339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27167339 |