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http://purl.uniprot.org/citations/27170266http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/27170266http://www.w3.org/2000/01/rdf-schema#comment"

Objectives

Impaired inhibitory control is a key feature of attention-deficit/hyperactivity disorder (ADHD). We investigated gene-environment interaction (GxE) as a possible contributing factor to response inhibition variation in context of the differential susceptibility theory. This states individuals carrying plasticity gene variants will be more disadvantaged in negative, but more advantaged in positive environments.

Methods

Behavioural and neural measures of response inhibition were assessed during a Stop-signal task in participants with (N = 197) and without (N = 295) ADHD, from N = 278 families (age M = 17.18, SD =3.65). We examined GxE between candidate plasticity genes (DAT1, 5-HTT, DRD4) and social environments (maternal expressed emotion, peer affiliation).

Results

A DRD4 × Positive peer affiliation interaction was found on the right fusiform gyrus (rFG) activation during successful inhibition. Further, 5-HTT short allele carriers showed increased rFG activation during failed inhibitions. Maternal warmth and positive peer affiliation were positively associated with right inferior frontal cortex activation during successful inhibition. Deviant peer affiliation was positively related to the error rate.

Conclusions

While a pattern of differential genetic susceptibility was found, more clarity on the role of the FG during response inhibition is warranted before firm conclusions can be made. Positive and negative social environments were related to inhibitory control. This extends previous research emphasizing adverse environments."xsd:string
http://purl.uniprot.org/citations/27170266http://purl.org/dc/terms/identifier"doi:10.3109/15622975.2016.1173724"xsd:string
http://purl.uniprot.org/citations/27170266http://purl.uniprot.org/core/author"Richards J.S."xsd:string
http://purl.uniprot.org/citations/27170266http://purl.uniprot.org/core/author"Faraone S.V."xsd:string
http://purl.uniprot.org/citations/27170266http://purl.uniprot.org/core/author"Franke B."xsd:string
http://purl.uniprot.org/citations/27170266http://purl.uniprot.org/core/author"Buitelaar J.K."xsd:string
http://purl.uniprot.org/citations/27170266http://purl.uniprot.org/core/author"Hoekstra P.J."xsd:string
http://purl.uniprot.org/citations/27170266http://purl.uniprot.org/core/author"Arias Vasquez A."xsd:string
http://purl.uniprot.org/citations/27170266http://purl.uniprot.org/core/author"Oosterlaan J."xsd:string
http://purl.uniprot.org/citations/27170266http://purl.uniprot.org/core/author"Hartman C.A."xsd:string
http://purl.uniprot.org/citations/27170266http://purl.uniprot.org/core/author"van der Meer D."xsd:string
http://purl.uniprot.org/citations/27170266http://purl.uniprot.org/core/author"Heslenfeld D.J."xsd:string
http://purl.uniprot.org/citations/27170266http://purl.uniprot.org/core/author"van Rooij D."xsd:string
http://purl.uniprot.org/citations/27170266http://purl.uniprot.org/core/date"2017"xsd:gYear
http://purl.uniprot.org/citations/27170266http://purl.uniprot.org/core/name"World J Biol Psychiatry"xsd:string
http://purl.uniprot.org/citations/27170266http://purl.uniprot.org/core/pages"308-321"xsd:string
http://purl.uniprot.org/citations/27170266http://purl.uniprot.org/core/title"Testing differential susceptibility: Plasticity genes, the social environment, and their interplay in adolescent response inhibition."xsd:string
http://purl.uniprot.org/citations/27170266http://purl.uniprot.org/core/volume"18"xsd:string
http://purl.uniprot.org/citations/27170266http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/27170266
http://purl.uniprot.org/citations/27170266http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/27170266
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http://purl.uniprot.org/uniprot/#_B3VRS5-mappedCitation-27170266http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27170266
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