Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/27170270http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/27170270http://www.w3.org/2000/01/rdf-schema#comment"

Background

Little is known regarding the role of redox balance regulators in metastatic melanomas, but there is some evidence for a link between epithelial-to-mesenchymal transition (EMT) and cellular redox status.

Methods

We compared the immunohistochemical expression of nuclear factor erythroid-2-related factor 2 (NFE2L2), Kelch-like ECH-associated protein 1 (KEAP1), 8-hydroxy-2'-deoxyguanosine (8-OHdG), TWIST1, SNAI2 and ZEB1 between primary melanomas and metastases in a cohort of 23 nevi, 66 malignant melanomas and 22 metastases.

Results

Nuclear NFE2L2 expression was higher (p=0.003) and cytoplasmic KEAP1 lower (p=0.026) in metastatic lesions than at primary sites. Nuclear NFE2L2 expression was associated with the presence of distant metastases (p=0.040) and with nuclear TWIST1 expression (p=0.002). Patients having both NFE2L2 and TWIST1 expression in nuclei had an extremely poor prognosis (p=0.0003). In multivariate analysis nuclear TWIST1 expression was an independent predictor of a poorer prognosis (HR 2.99, 95% CI 1.17-7.69; p=0.023) and the invasive TWIST1/ZEB1 phenotype showed poorer melanoma-specific survival (HR 7.28, 95% CI 2.23-23.77; p=0.001). Nuclear expression of 8-OHdG (p=0.001) was lower at metastatic sites than in primary lesions.

Conclusions

EMT signalling and the KEAP1/NFE2L2-axis are likely to be involved in metastatic spread of malignant melanoma and also appear to have potential interactions."xsd:string
http://purl.uniprot.org/citations/27170270http://purl.org/dc/terms/identifier"doi:10.14670/hh-11-778"xsd:string
http://purl.uniprot.org/citations/27170270http://purl.uniprot.org/core/author"Soini Y."xsd:string
http://purl.uniprot.org/citations/27170270http://purl.uniprot.org/core/author"Karihtala P."xsd:string
http://purl.uniprot.org/citations/27170270http://purl.uniprot.org/core/author"Haapasaari K.M."xsd:string
http://purl.uniprot.org/citations/27170270http://purl.uniprot.org/core/author"Hintsala H.R."xsd:string
http://purl.uniprot.org/citations/27170270http://purl.uniprot.org/core/date"2017"xsd:gYear
http://purl.uniprot.org/citations/27170270http://purl.uniprot.org/core/name"Histol Histopathol"xsd:string
http://purl.uniprot.org/citations/27170270http://purl.uniprot.org/core/pages"129-136"xsd:string
http://purl.uniprot.org/citations/27170270http://purl.uniprot.org/core/title"An immunohistochemical study of NFE2L2, KEAP1 and 8-hydroxy-2'-deoxyguanosine and the EMT markers SNAI2, ZEB1 and TWIST1 in metastatic melanoma."xsd:string
http://purl.uniprot.org/citations/27170270http://purl.uniprot.org/core/volume"32"xsd:string
http://purl.uniprot.org/citations/27170270http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/27170270
http://purl.uniprot.org/citations/27170270http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/27170270
http://purl.uniprot.org/uniprot/#_E2I973-mappedCitation-27170270http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27170270
http://purl.uniprot.org/uniprot/#_Q14145-mappedCitation-27170270http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27170270
http://purl.uniprot.org/uniprot/#_Q15672-mappedCitation-27170270http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27170270
http://purl.uniprot.org/uniprot/#_B7ZA33-mappedCitation-27170270http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27170270
http://purl.uniprot.org/uniprot/#_A0A8V8TN14-mappedCitation-27170270http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27170270
http://purl.uniprot.org/uniprot/#_A0A8V8TPA8-mappedCitation-27170270http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27170270
http://purl.uniprot.org/uniprot/#_A0A2P1M8C0-mappedCitation-27170270http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27170270
http://purl.uniprot.org/uniprot/#_B4DNB0-mappedCitation-27170270http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27170270
http://purl.uniprot.org/uniprot/#_Q16236-mappedCitation-27170270http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27170270
http://purl.uniprot.org/uniprot/#_Q9BZF8-mappedCitation-27170270http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27170270
http://purl.uniprot.org/uniprot/Q16236http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/27170270
▶