| http://purl.uniprot.org/citations/27173727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27173727 | http://www.w3.org/2000/01/rdf-schema#comment | "Citrullination is a post-translational modification of arginine that commonly occurs in inflammatory tissues. Because T-cell receptor (TCR) signal quantity and quality can regulate T-cell differentiation, citrullination within a T-cell epitope has potential implications for T-cell effector function. Here, we investigated how citrullination of an immunedominant T-cell epitope affected Th17 development. Murine naïve CD4(+) T cells with a transgenic TCR recognising p89-103 of the G1 domain of aggrecan (agg) were co-cultured with syngeneic bone marrow-derived dendritic cells (BMDC) presenting the native or citrullinated peptides. In the presence of pro-Th17 cytokines, the peptide citrullinated on residue 93 (R93Cit) significantly enhanced Th17 development whilst impairing the Th2 response, compared to the native peptide. T cells responding to R93Cit produced less IL-2, expressed lower levels of the IL-2 receptor subunit CD25, and showed reduced STAT5 phosphorylation, whilst STAT3 activation was unaltered. IL-2 blockade in native p89-103-primed T cells enhanced the phosphorylated STAT3/STAT5 ratio, and concomitantly enhanced Th17 development. Our data illustrate how a post-translational modification of a TCR contact point may promote Th17 development by altering the balance between STAT5 and STAT3 activation in responding T cells, and provide new insight into how protein citrullination may influence effector Th-cell development in inflammatory disorders."xsd:string |
| http://purl.uniprot.org/citations/27173727 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201546217"xsd:string |
| http://purl.uniprot.org/citations/27173727 | http://purl.uniprot.org/core/author | "Robinson J.H."xsd:string |
| http://purl.uniprot.org/citations/27173727 | http://purl.uniprot.org/core/author | "van Eden W."xsd:string |
| http://purl.uniprot.org/citations/27173727 | http://purl.uniprot.org/core/author | "Stoop J."xsd:string |
| http://purl.uniprot.org/citations/27173727 | http://purl.uniprot.org/core/author | "Falconer J."xsd:string |
| http://purl.uniprot.org/citations/27173727 | http://purl.uniprot.org/core/author | "Hilkens C.M."xsd:string |
| http://purl.uniprot.org/citations/27173727 | http://purl.uniprot.org/core/author | "Tibbitt C."xsd:string |
| http://purl.uniprot.org/citations/27173727 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27173727 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/27173727 | http://purl.uniprot.org/core/pages | "1633-1643"xsd:string |
| http://purl.uniprot.org/citations/27173727 | http://purl.uniprot.org/core/title | "Reduced TCR-dependent activation through citrullination of a T-cell epitope enhances Th17 development by disruption of the STAT3/5 balance."xsd:string |
| http://purl.uniprot.org/citations/27173727 | http://purl.uniprot.org/core/volume | "46"xsd:string |
| http://purl.uniprot.org/citations/27173727 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27173727 |
| http://purl.uniprot.org/citations/27173727 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27173727 |
| http://purl.uniprot.org/uniprot/#_A8K6I5-mappedCitation-27173727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27173727 |
| http://purl.uniprot.org/uniprot/#_B7ZA24-mappedCitation-27173727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27173727 |
| http://purl.uniprot.org/uniprot/#_A0A384N5W4-mappedCitation-27173727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27173727 |
| http://purl.uniprot.org/uniprot/#_A0A7I2V395-mappedCitation-27173727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27173727 |
| http://purl.uniprot.org/uniprot/#_B4DNP0-mappedCitation-27173727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27173727 |
| http://purl.uniprot.org/uniprot/#_B4DVR6-mappedCitation-27173727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27173727 |
| http://purl.uniprot.org/uniprot/#_B5BTZ6-mappedCitation-27173727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27173727 |
| http://purl.uniprot.org/uniprot/#_K7EK35-mappedCitation-27173727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27173727 |
| http://purl.uniprot.org/uniprot/#_P40763-mappedCitation-27173727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27173727 |