| http://purl.uniprot.org/citations/27184078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27184078 | http://www.w3.org/2000/01/rdf-schema#comment | "Smads are nuclear-shuttling transcriptional mediators of transforming growth factor-β (TGF-β) signaling. Although their essential nuclear roles in gene regulation during development and carcinogenesis are well established, whether they have important cytoplasmic functions remains unclear. Here we report that Smad2 is a critical determinant of mitochondrial dynamics. We identified mitofusin2 (MFN2) and Rab and Ras Interactor 1 (RIN1) as new Smad2 binding partners required for mitochondrial fusion. Unlike TGF-β-induced Smad2/3 transcriptional responses underlying mitochondrial fragmentation and apoptosis, inactive cytoplasmic Smad2 rapidly promotes mitochondrial fusion by recruiting RIN1 into a complex with MFN2. We demonstrate that Smad2 is a key scaffold, allowing RIN1 to act as a GTP exchange factor for MFN2-GTPase activation to promote mitochondrial ATP synthesis and suppress superoxide production. These results reveal functional implications between Smads and mitochondrial dysfunction in cancer and metabolic and neurodegenerative disorders."xsd:string |
| http://purl.uniprot.org/citations/27184078 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2016.04.010"xsd:string |
| http://purl.uniprot.org/citations/27184078 | http://purl.uniprot.org/core/author | "Kumar S."xsd:string |
| http://purl.uniprot.org/citations/27184078 | http://purl.uniprot.org/core/author | "Shah N."xsd:string |
| http://purl.uniprot.org/citations/27184078 | http://purl.uniprot.org/core/author | "Lee N.Y."xsd:string |
| http://purl.uniprot.org/citations/27184078 | http://purl.uniprot.org/core/author | "Hempel N."xsd:string |
| http://purl.uniprot.org/citations/27184078 | http://purl.uniprot.org/core/author | "Hoyt K.R."xsd:string |
| http://purl.uniprot.org/citations/27184078 | http://purl.uniprot.org/core/author | "Wheeler S.E."xsd:string |
| http://purl.uniprot.org/citations/27184078 | http://purl.uniprot.org/core/author | "Pan C.C."xsd:string |
| http://purl.uniprot.org/citations/27184078 | http://purl.uniprot.org/core/author | "Mythreye K."xsd:string |
| http://purl.uniprot.org/citations/27184078 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27184078 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/27184078 | http://purl.uniprot.org/core/pages | "520-531"xsd:string |
| http://purl.uniprot.org/citations/27184078 | http://purl.uniprot.org/core/title | "Activation of Mitofusin2 by Smad2-RIN1 Complex during Mitochondrial Fusion."xsd:string |
| http://purl.uniprot.org/citations/27184078 | http://purl.uniprot.org/core/volume | "62"xsd:string |
| http://purl.uniprot.org/citations/27184078 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27184078 |
| http://purl.uniprot.org/citations/27184078 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27184078 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4T3-mappedCitation-27184078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27184078 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4T5-mappedCitation-27184078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27184078 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4U0-mappedCitation-27184078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27184078 |
| http://purl.uniprot.org/uniprot/#_B3KMR3-mappedCitation-27184078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27184078 |
| http://purl.uniprot.org/uniprot/#_B3KM52-mappedCitation-27184078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27184078 |
| http://purl.uniprot.org/uniprot/#_A6NLD2-mappedCitation-27184078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27184078 |
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