| http://purl.uniprot.org/citations/27184118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27184118 | http://www.w3.org/2000/01/rdf-schema#comment | "The Stac3 gene is exclusively expressed in skeletal muscle, and Stac3 knockout is perinatal lethal in mice. Previous data from Stac3-deleted diaphragms indicated that Stac3-deleted skeletal muscle could not contract because of defective excitation-contraction (EC) coupling. In this study, we determined the contractility of Stac3-deleted hindlimb muscle. In response to frequent electrostimulation, Stac3-deleted hindlimb muscle contracted but the maximal tension generated was only 20% of that in control (wild type or heterozygous) muscle (P < 0.05). In response to high [K(+)], caffeine, and 4-chloro-m-cresol (4-CMC), the maximal tensions generated in Stac3-deleted muscle were 29% (P < 0.05), 58% (P = 0.08), and 55% (P < 0.05) of those in control muscle, respectively. In response to 4-CMC or caffeine, over 90% of myotubes formed from control myoblasts contracted, but only 60% of myotubes formed from Stac3-deleted myoblasts contracted (P = 0.05). However, in response to 4-CMC or caffeine, similar increases in intracellular calcium concentration were observed in Stac3-deleted and control myotubes. Gene expression and histological analyses revealed that Stac3-deleted hindlimb muscle contained more slow type-like fibers than control muscle. These data together confirm a critical role of STAC3 in EC coupling but also suggest that STAC3 may have additional functions in skeletal muscle, at least in the hindlimb muscle."xsd:string |
| http://purl.uniprot.org/citations/27184118 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep26194"xsd:string |
| http://purl.uniprot.org/citations/27184118 | http://purl.uniprot.org/core/author | "Jiang H."xsd:string |
| http://purl.uniprot.org/citations/27184118 | http://purl.uniprot.org/core/author | "Cong X."xsd:string |
| http://purl.uniprot.org/citations/27184118 | http://purl.uniprot.org/core/author | "Doering J."xsd:string |
| http://purl.uniprot.org/citations/27184118 | http://purl.uniprot.org/core/author | "Grange R.W."xsd:string |
| http://purl.uniprot.org/citations/27184118 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27184118 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/27184118 | http://purl.uniprot.org/core/pages | "26194"xsd:string |
| http://purl.uniprot.org/citations/27184118 | http://purl.uniprot.org/core/title | "Defective excitation-contraction coupling is partially responsible for impaired contractility in hindlimb muscles of Stac3 knockout mice."xsd:string |
| http://purl.uniprot.org/citations/27184118 | http://purl.uniprot.org/core/volume | "6"xsd:string |
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