| http://purl.uniprot.org/citations/27184844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27184844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27184844 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanisms that tightly control the transcription of host defense genes have not been fully elucidated. We previously identified TFEB as a transcription factor important for host defense, but the mechanisms that regulate TFEB during infection remained unknown. Here, we used C. elegans to discover a pathway that activates TFEB during infection. Gene dkf-1, which encodes a homolog of protein kinase D (PKD), was required for TFEB activation in nematodes infected with Staphylococcus aureus. Conversely, pharmacological activation of PKD was sufficient to activate TFEB. Furthermore, phospholipase C (PLC) gene plc-1 was also required for TFEB activation, downstream of Gαq homolog egl-30 and upstream of dkf-1. Using reverse and chemical genetics, we discovered a similar PLC-PKD-TFEB axis in Salmonella-infected mouse macrophages. In addition, PKCα was required in macrophages. These observations reveal a previously unknown host defense signaling pathway, which has been conserved across one billion years of evolution."xsd:string |
| http://purl.uniprot.org/citations/27184844 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2016.04.052"xsd:string |
| http://purl.uniprot.org/citations/27184844 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2016.04.052"xsd:string |
| http://purl.uniprot.org/citations/27184844 | http://purl.uniprot.org/core/author | "Irazoqui J.E."xsd:string |
| http://purl.uniprot.org/citations/27184844 | http://purl.uniprot.org/core/author | "Irazoqui J.E."xsd:string |
| http://purl.uniprot.org/citations/27184844 | http://purl.uniprot.org/core/author | "Labed S.A."xsd:string |
| http://purl.uniprot.org/citations/27184844 | http://purl.uniprot.org/core/author | "Labed S.A."xsd:string |
| http://purl.uniprot.org/citations/27184844 | http://purl.uniprot.org/core/author | "Najibi M."xsd:string |
| http://purl.uniprot.org/citations/27184844 | http://purl.uniprot.org/core/author | "Najibi M."xsd:string |
| http://purl.uniprot.org/citations/27184844 | http://purl.uniprot.org/core/author | "Visvikis O."xsd:string |
| http://purl.uniprot.org/citations/27184844 | http://purl.uniprot.org/core/author | "Visvikis O."xsd:string |
| http://purl.uniprot.org/citations/27184844 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27184844 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27184844 | http://purl.uniprot.org/core/name | "Cell Rep."xsd:string |
| http://purl.uniprot.org/citations/27184844 | http://purl.uniprot.org/core/name | "Cell Rep."xsd:string |
| http://purl.uniprot.org/citations/27184844 | http://purl.uniprot.org/core/pages | "1728-1742"xsd:string |
| http://purl.uniprot.org/citations/27184844 | http://purl.uniprot.org/core/pages | "1728-1742"xsd:string |
| http://purl.uniprot.org/citations/27184844 | http://purl.uniprot.org/core/title | "An evolutionarily conserved PLC-PKD-TFEB pathway for host defense."xsd:string |
| http://purl.uniprot.org/citations/27184844 | http://purl.uniprot.org/core/title | "An evolutionarily conserved PLC-PKD-TFEB pathway for host defense."xsd:string |
| http://purl.uniprot.org/citations/27184844 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/27184844 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/27184844 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27184844 |
| http://purl.uniprot.org/citations/27184844 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27184844 |