| http://purl.uniprot.org/citations/27184852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27184852 | http://www.w3.org/2000/01/rdf-schema#comment | "Inhalation of environmental antigens such as allergens does not always induce inflammation in the respiratory tract. While antigen-presenting cells (APCs), including dendritic cells and macrophages, take up inhaled antigens, the cell-intrinsic molecular mechanisms that prevent an inflammatory response during this process, such as activation of the transcription factor NF-κB, are not well understood. Here, we show that the nuclear receptor PPARγ plays a critical role in blocking NF-κB activation in response to inhaled antigens to preserve immune tolerance. Tolerance induction promoted mitochondrial respiration, generation of H2O2, and suppression of NF-κB activation in WT, but not PPARγ-deficient, APCs. Forced restoration of H2O2 in PPARγ-deficient cells suppressed IκBα degradation and NF-κB activation. Conversely, scavenging reactive oxygen species from mitochondria promoted IκBα degradation with loss of regulatory and promotion of inflammatory T cell responses in vivo. Thus, communication between PPARγ and the mitochondria maintains immune quiescence in the airways."xsd:string |
| http://purl.uniprot.org/citations/27184852 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2016.04.060"xsd:string |
| http://purl.uniprot.org/citations/27184852 | http://purl.uniprot.org/core/author | "Das S."xsd:string |
| http://purl.uniprot.org/citations/27184852 | http://purl.uniprot.org/core/author | "Ray P."xsd:string |
| http://purl.uniprot.org/citations/27184852 | http://purl.uniprot.org/core/author | "Ray A."xsd:string |
| http://purl.uniprot.org/citations/27184852 | http://purl.uniprot.org/core/author | "Watkins S.C."xsd:string |
| http://purl.uniprot.org/citations/27184852 | http://purl.uniprot.org/core/author | "Chakraborty K."xsd:string |
| http://purl.uniprot.org/citations/27184852 | http://purl.uniprot.org/core/author | "Corey C."xsd:string |
| http://purl.uniprot.org/citations/27184852 | http://purl.uniprot.org/core/author | "Shiva S."xsd:string |
| http://purl.uniprot.org/citations/27184852 | http://purl.uniprot.org/core/author | "St Croix C."xsd:string |
| http://purl.uniprot.org/citations/27184852 | http://purl.uniprot.org/core/author | "Quesnelle K."xsd:string |
| http://purl.uniprot.org/citations/27184852 | http://purl.uniprot.org/core/author | "Khare A."xsd:string |
| http://purl.uniprot.org/citations/27184852 | http://purl.uniprot.org/core/author | "Oriss T.B."xsd:string |
| http://purl.uniprot.org/citations/27184852 | http://purl.uniprot.org/core/author | "Morse C."xsd:string |
| http://purl.uniprot.org/citations/27184852 | http://purl.uniprot.org/core/author | "Huff R."xsd:string |
| http://purl.uniprot.org/citations/27184852 | http://purl.uniprot.org/core/author | "Raundhal M."xsd:string |
| http://purl.uniprot.org/citations/27184852 | http://purl.uniprot.org/core/author | "Hannum R."xsd:string |
| http://purl.uniprot.org/citations/27184852 | http://purl.uniprot.org/core/author | "Kamga C.K."xsd:string |
| http://purl.uniprot.org/citations/27184852 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27184852 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/27184852 | http://purl.uniprot.org/core/pages | "1700-1714"xsd:string |
| http://purl.uniprot.org/citations/27184852 | http://purl.uniprot.org/core/title | "Mitochondrial H2O2 in Lung Antigen-Presenting Cells Blocks NF-kappaB Activation to Prevent Unwarranted Immune Activation."xsd:string |
| http://purl.uniprot.org/citations/27184852 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/27184852 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27184852 |