| http://purl.uniprot.org/citations/27185732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27185732 | http://www.w3.org/2000/01/rdf-schema#comment | "Although mutations in HNF4A were identified as the cause of Maturity Onset Diabetes of the Young 1 (MODY1) two decades ago, the mechanisms by which this nuclear receptor regulates glucose homeostasis remain unclear. Here we report that loss of Drosophila HNF4 recapitulates hallmark symptoms of MODY1, including adult-onset hyperglycemia, glucose intolerance and impaired glucose-stimulated insulin secretion (GSIS). These defects are linked to a role for dHNF4 in promoting mitochondrial function as well as the expression of Hex-C, a homolog of the MODY2 gene Glucokinase. dHNF4 is required in the fat body and insulin-producing cells to maintain glucose homeostasis by supporting a developmental switch toward oxidative phosphorylation and GSIS at the transition to adulthood. These findings establish an animal model for MODY1 and define a developmental reprogramming of metabolism to support the energetic needs of the mature animal."xsd:string |
| http://purl.uniprot.org/citations/27185732 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.11183"xsd:string |
| http://purl.uniprot.org/citations/27185732 | http://purl.uniprot.org/core/author | "Thummel C.S."xsd:string |
| http://purl.uniprot.org/citations/27185732 | http://purl.uniprot.org/core/author | "Barry W.E."xsd:string |
| http://purl.uniprot.org/citations/27185732 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27185732 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/27185732 | http://purl.uniprot.org/core/pages | "e11183"xsd:string |
| http://purl.uniprot.org/citations/27185732 | http://purl.uniprot.org/core/title | "The Drosophila HNF4 nuclear receptor promotes glucose-stimulated insulin secretion and mitochondrial function in adults."xsd:string |
| http://purl.uniprot.org/citations/27185732 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/27185732 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27185732 |
| http://purl.uniprot.org/citations/27185732 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27185732 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFT0-mappedCitation-27185732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27185732 |
| http://purl.uniprot.org/uniprot/#_P49866-mappedCitation-27185732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27185732 |
| http://purl.uniprot.org/uniprot/#_P00850-mappedCitation-27185732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27185732 |
| http://purl.uniprot.org/uniprot/#_P84345-mappedCitation-27185732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27185732 |
| http://purl.uniprot.org/uniprot/#_L0MQ04-mappedCitation-27185732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27185732 |
| http://purl.uniprot.org/uniprot/#_P09208-mappedCitation-27185732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27185732 |
| http://purl.uniprot.org/uniprot/#_P18929-mappedCitation-27185732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27185732 |
| http://purl.uniprot.org/uniprot/#_P18931-mappedCitation-27185732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27185732 |
| http://purl.uniprot.org/uniprot/#_P18932-mappedCitation-27185732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27185732 |
| http://purl.uniprot.org/uniprot/#_P18935-mappedCitation-27185732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27185732 |
| http://purl.uniprot.org/uniprot/#_Q7GHL2-mappedCitation-27185732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27185732 |
| http://purl.uniprot.org/uniprot/#_Q7JYW9-mappedCitation-27185732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27185732 |
| http://purl.uniprot.org/uniprot/#_P00399-mappedCitation-27185732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27185732 |