| http://purl.uniprot.org/citations/27203177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27203177 | http://www.w3.org/2000/01/rdf-schema#comment | "UV-induced DNA damage, a major risk factor for skin cancers, is primarily repaired by nucleotide excision repair (NER). UV radiation resistance-associated gene (UVRAG) is a tumor suppressor involved in autophagy. It was initially isolated as a cDNA partially complementing UV sensitivity in xeroderma pigmentosum (XP), but this was not explored further. Here we show that UVRAG plays an integral role in UV-induced DNA damage repair. It localizes to photolesions and associates with DDB1 to promote the assembly and activity of the DDB2-DDB1-Cul4A-Roc1 (CRL4(DDB2)) ubiquitin ligase complex, leading to efficient XPC recruitment and global genomic NER. UVRAG depletion decreased substrate handover to XPC and conferred UV-damage hypersensitivity. We confirmed the importance of UVRAG for UV-damage tolerance using a Drosophila model. Furthermore, increased UV-signature mutations in melanoma correlate with reduced expression of UVRAG. Our results identify UVRAG as a regulator of CRL4(DDB2)-mediated NER and suggest that its expression levels may influence melanoma predisposition."xsd:string |
| http://purl.uniprot.org/citations/27203177 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2016.04.014"xsd:string |
| http://purl.uniprot.org/citations/27203177 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/27203177 | http://purl.uniprot.org/core/author | "He S."xsd:string |
| http://purl.uniprot.org/citations/27203177 | http://purl.uniprot.org/core/author | "Li F."xsd:string |
| http://purl.uniprot.org/citations/27203177 | http://purl.uniprot.org/core/author | "Liang C."xsd:string |
| http://purl.uniprot.org/citations/27203177 | http://purl.uniprot.org/core/author | "Oh B.H."xsd:string |
| http://purl.uniprot.org/citations/27203177 | http://purl.uniprot.org/core/author | "Wang Q."xsd:string |
| http://purl.uniprot.org/citations/27203177 | http://purl.uniprot.org/core/author | "Zhang T."xsd:string |
| http://purl.uniprot.org/citations/27203177 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/27203177 | http://purl.uniprot.org/core/author | "Yuan Z."xsd:string |
| http://purl.uniprot.org/citations/27203177 | http://purl.uniprot.org/core/author | "Choi Y."xsd:string |
| http://purl.uniprot.org/citations/27203177 | http://purl.uniprot.org/core/author | "Kwak M.J."xsd:string |
| http://purl.uniprot.org/citations/27203177 | http://purl.uniprot.org/core/author | "Jeon Y.H."xsd:string |
| http://purl.uniprot.org/citations/27203177 | http://purl.uniprot.org/core/author | "Chimge N.O."xsd:string |
| http://purl.uniprot.org/citations/27203177 | http://purl.uniprot.org/core/author | "Frenkel B."xsd:string |
| http://purl.uniprot.org/citations/27203177 | http://purl.uniprot.org/core/author | "O'Connell D."xsd:string |
| http://purl.uniprot.org/citations/27203177 | http://purl.uniprot.org/core/author | "Pirooz S.D."xsd:string |
| http://purl.uniprot.org/citations/27203177 | http://purl.uniprot.org/core/author | "Aldrovandi G.M."xsd:string |
| http://purl.uniprot.org/citations/27203177 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27203177 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/27203177 | http://purl.uniprot.org/core/pages | "507-519"xsd:string |
| http://purl.uniprot.org/citations/27203177 | http://purl.uniprot.org/core/title | "Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4(DDB2) E3 Ligase."xsd:string |
| http://purl.uniprot.org/citations/27203177 | http://purl.uniprot.org/core/volume | "62"xsd:string |