| http://purl.uniprot.org/citations/27203443 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27203443 | http://www.w3.org/2000/01/rdf-schema#comment | "microRNAs or miRs have been shown to be pivotal modulators of vascular development. The strand and cell type-specific function of miR-126 in angiogenesis, especially pathological angiogenesis, remains poorly defined. We characterized the retinal vascular phenotype of miR-126-/- mice, and tested the function of miR-126 strands (miR-126-3p and -5p) using in vitro angiogenesis models and a mouse model of neovascular age-related macular degeneration. We found that miR-126 is critical for retinal vascular development but has dual function in pathological angiogenesis. miR-126-/- mice showed defective postnatal retinal vascular development and remodeling, which is partially rescued by genetic knockout of its target gene Spred-1. Surprisingly, either silencing miR-126-3p by LNA-antimiR or overexpressing miR-126-3p by miRNA mimic repressed laser-induced choroidal neovascularization. To dissect the underlying mechanism, we found in endothelial cells, silencing of miR-126-3p repressed angiogenesis, while overexpression of miR-126-5p enhanced angiogenesis. However, in retinal pigment epithelial cells, miR-126-3p repressed vascular endothelial growth factor (VEGF-A) expression via a novel mechanism of regulating αB-Crystallin promoter activity and by directly targeting VEGF-A 3'-untranslated region. These findings provide first genetic evidence that miR-126 is required for the development of different retinal vascular layers, and also uncover a strand and cell type-specific function of miR-126 in ocular pathological angiogenesis."xsd:string |
| http://purl.uniprot.org/citations/27203443 | http://purl.org/dc/terms/identifier | "doi:10.1038/mt.2016.108"xsd:string |
| http://purl.uniprot.org/citations/27203443 | http://purl.uniprot.org/core/author | "Ma J."xsd:string |
| http://purl.uniprot.org/citations/27203443 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/27203443 | http://purl.uniprot.org/core/author | "Zhou Q."xsd:string |
| http://purl.uniprot.org/citations/27203443 | http://purl.uniprot.org/core/author | "Zhao F."xsd:string |
| http://purl.uniprot.org/citations/27203443 | http://purl.uniprot.org/core/author | "Yoshimura A."xsd:string |
| http://purl.uniprot.org/citations/27203443 | http://purl.uniprot.org/core/author | "Anderson C."xsd:string |
| http://purl.uniprot.org/citations/27203443 | http://purl.uniprot.org/core/author | "Hanus J."xsd:string |
| http://purl.uniprot.org/citations/27203443 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27203443 | http://purl.uniprot.org/core/name | "Mol Ther"xsd:string |
| http://purl.uniprot.org/citations/27203443 | http://purl.uniprot.org/core/pages | "1823-1835"xsd:string |
| http://purl.uniprot.org/citations/27203443 | http://purl.uniprot.org/core/title | "Strand and Cell Type-specific Function of microRNA-126 in Angiogenesis."xsd:string |
| http://purl.uniprot.org/citations/27203443 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/27203443 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27203443 |
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