| http://purl.uniprot.org/citations/27211802 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27211802 | http://www.w3.org/2000/01/rdf-schema#comment | "The human Hole gene (hHole) encodes a six-transmembrane protein with 319-amino acids. Our previous study showed that hHole was strongly expressed in adult heart and may act as a suppressor of extracellular signal-regulated kinases (ERKs), overactivation of which contributed to pathological cardiac hypertrophy. In this study, it was observed that Hole expression was up-regulated in murine hypertrophic hearts. In a cardiac specific transgenic mouse model, it was observed that overexpression of hHole specifically in heart attenuated cardiac hypertrophy and fibrosis induced by isoproterenol (ISO), with blunted transcriptions of ERK1/2, total ERK1/2 proteins and phosphorylated ERK1/2 (p-ERK1/2) levels. Furthermore, overexpression of hHole in mice by hydrodynamic tail-vein injection with hHole plamids also inhibited cardiac hypertrophy induced by ISO. Our work identified hHole as a novel repressor of cardiac hypertrophy, and provided new insights into the possible target for the prevention or treatment of cardiac diseases."xsd:string |
| http://purl.uniprot.org/citations/27211802 | http://purl.org/dc/terms/identifier | "doi:10.2174/1566524016666160523143704"xsd:string |
| http://purl.uniprot.org/citations/27211802 | http://purl.uniprot.org/core/author | "Chen F."xsd:string |
| http://purl.uniprot.org/citations/27211802 | http://purl.uniprot.org/core/author | "Deng Y."xsd:string |
| http://purl.uniprot.org/citations/27211802 | http://purl.uniprot.org/core/author | "Fan X."xsd:string |
| http://purl.uniprot.org/citations/27211802 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/27211802 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/27211802 | http://purl.uniprot.org/core/author | "Luo S."xsd:string |
| http://purl.uniprot.org/citations/27211802 | http://purl.uniprot.org/core/author | "Peng X."xsd:string |
| http://purl.uniprot.org/citations/27211802 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/27211802 | http://purl.uniprot.org/core/author | "Zeng Q."xsd:string |
| http://purl.uniprot.org/citations/27211802 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/27211802 | http://purl.uniprot.org/core/author | "Xu W."xsd:string |
| http://purl.uniprot.org/citations/27211802 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/27211802 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/27211802 | http://purl.uniprot.org/core/author | "Zhu X."xsd:string |
| http://purl.uniprot.org/citations/27211802 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/27211802 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
| http://purl.uniprot.org/citations/27211802 | http://purl.uniprot.org/core/author | "Wan Y."xsd:string |
| http://purl.uniprot.org/citations/27211802 | http://purl.uniprot.org/core/author | "Yuan W."xsd:string |
| http://purl.uniprot.org/citations/27211802 | http://purl.uniprot.org/core/author | "Ye X."xsd:string |
| http://purl.uniprot.org/citations/27211802 | http://purl.uniprot.org/core/author | "Cao L."xsd:string |
| http://purl.uniprot.org/citations/27211802 | http://purl.uniprot.org/core/author | "Jiang Z."xsd:string |
| http://purl.uniprot.org/citations/27211802 | http://purl.uniprot.org/core/author | "Mo X."xsd:string |