| http://purl.uniprot.org/citations/27212270 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27212270 | http://www.w3.org/2000/01/rdf-schema#comment | "The spreading of adhering cells is a morphogenetic process during which cells break spherical or radial symmetry and adopt migratory polarity with spatially segregated protruding cell front and non-protruding cell rear. The organization and regulation of these symmetry-breaking events, which are both complex and stochastic, are not fully understood. Here we show that in radially spreading cells, symmetry breaking commences with the development of discrete non-protruding regions characterized by large but sparse focal adhesions and long peripheral actin bundles. Establishment of this non-protruding static region specifies the distally oriented protruding cell front and thus determines the polarity axis and the direction of cell migration. The development of non-protruding regions requires ERK2 and the ERK pathway scaffold protein RACK1. RACK1 promotes adhesion-mediated activation of ERK2 that in turn inhibits p190A-RhoGAP signaling by reducing the peripheral localization of p190A-RhoGAP. We propose that sustained ERK signaling at the prospective cell rear induces p190A-RhoGAP depletion from the cell periphery resulting in peripheral actin bundles and cell rear formation. Since cell adhesion activates both ERK and p190A-RhoGAP signaling this constitutes a spatially confined incoherent feed-forward signaling circuit."xsd:string |
| http://purl.uniprot.org/citations/27212270 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbamcr.2016.05.013"xsd:string |
| http://purl.uniprot.org/citations/27212270 | http://purl.uniprot.org/core/author | "Weber M.J."xsd:string |
| http://purl.uniprot.org/citations/27212270 | http://purl.uniprot.org/core/author | "Klimova Z."xsd:string |
| http://purl.uniprot.org/citations/27212270 | http://purl.uniprot.org/core/author | "Vomastek T."xsd:string |
| http://purl.uniprot.org/citations/27212270 | http://purl.uniprot.org/core/author | "Braborec V."xsd:string |
| http://purl.uniprot.org/citations/27212270 | http://purl.uniprot.org/core/author | "Caslavsky J."xsd:string |
| http://purl.uniprot.org/citations/27212270 | http://purl.uniprot.org/core/author | "Maninova M."xsd:string |
| http://purl.uniprot.org/citations/27212270 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27212270 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/27212270 | http://purl.uniprot.org/core/pages | "2189-2200"xsd:string |
| http://purl.uniprot.org/citations/27212270 | http://purl.uniprot.org/core/title | "Symmetry breaking in spreading RAT2 fibroblasts requires the MAPK/ERK pathway scaffold RACK1 that integrates FAK, p190A-RhoGAP and ERK2 signaling."xsd:string |
| http://purl.uniprot.org/citations/27212270 | http://purl.uniprot.org/core/volume | "1863"xsd:string |
| http://purl.uniprot.org/citations/27212270 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27212270 |
| http://purl.uniprot.org/citations/27212270 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27212270 |
| http://purl.uniprot.org/uniprot/#_P63086-mappedCitation-27212270 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27212270 |
| http://purl.uniprot.org/uniprot/#_A6HDT8-mappedCitation-27212270 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27212270 |
| http://purl.uniprot.org/uniprot/#_A6HDT9-mappedCitation-27212270 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27212270 |
| http://purl.uniprot.org/uniprot/#_A6JSN9-mappedCitation-27212270 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27212270 |
| http://purl.uniprot.org/uniprot/#_A6HRV3-mappedCitation-27212270 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27212270 |
| http://purl.uniprot.org/uniprot/#_A6HRV4-mappedCitation-27212270 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27212270 |
| http://purl.uniprot.org/uniprot/#_A6HRV5-mappedCitation-27212270 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27212270 |
| http://purl.uniprot.org/uniprot/#_O35346-mappedCitation-27212270 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27212270 |
| http://purl.uniprot.org/uniprot/#_P81128-mappedCitation-27212270 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27212270 |