| http://purl.uniprot.org/citations/27217060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27217060 | http://www.w3.org/2000/01/rdf-schema#comment | "During apoptosis, Bak and Bax are activated by BH3-only proteins binding to the α2-α5 hydrophobic groove; Bax is also activated via a rear pocket. Here we report that antibodies can directly activate Bak and mitochondrial Bax by binding to the α1-α2 loop. A monoclonal antibody (clone 7D10) binds close to α1 in non-activated Bak to induce conformational change, oligomerization, and cytochrome c release. Anti-FLAG antibodies also activate Bak containing a FLAG epitope close to α1. An antibody (clone 3C10) to the Bax α1-α2 loop activates mitochondrial Bax, but blocks translocation of cytosolic Bax. Tethers within Bak show that 7D10 binding directly extricates α1; a structural model of the 7D10 Fab bound to Bak reveals the formation of a cavity under α1. Our identification of the α1-α2 loop as an activation site in Bak paves the way to develop intrabodies or small molecules that directly and selectively regulate these proteins."xsd:string |
| http://purl.uniprot.org/citations/27217060 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms11734"xsd:string |
| http://purl.uniprot.org/citations/27217060 | http://purl.uniprot.org/core/author | "Dewson G."xsd:string |
| http://purl.uniprot.org/citations/27217060 | http://purl.uniprot.org/core/author | "Smith B.J."xsd:string |
| http://purl.uniprot.org/citations/27217060 | http://purl.uniprot.org/core/author | "Huang D.C."xsd:string |
| http://purl.uniprot.org/citations/27217060 | http://purl.uniprot.org/core/author | "Smith N.A."xsd:string |
| http://purl.uniprot.org/citations/27217060 | http://purl.uniprot.org/core/author | "Carroll J."xsd:string |
| http://purl.uniprot.org/citations/27217060 | http://purl.uniprot.org/core/author | "Iyer S."xsd:string |
| http://purl.uniprot.org/citations/27217060 | http://purl.uniprot.org/core/author | "Kluck R.M."xsd:string |
| http://purl.uniprot.org/citations/27217060 | http://purl.uniprot.org/core/author | "Alsop A.E."xsd:string |
| http://purl.uniprot.org/citations/27217060 | http://purl.uniprot.org/core/author | "Yuen W.S."xsd:string |
| http://purl.uniprot.org/citations/27217060 | http://purl.uniprot.org/core/author | "Anwari K."xsd:string |
| http://purl.uniprot.org/citations/27217060 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27217060 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/27217060 | http://purl.uniprot.org/core/pages | "11734"xsd:string |
| http://purl.uniprot.org/citations/27217060 | http://purl.uniprot.org/core/title | "Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies."xsd:string |
| http://purl.uniprot.org/citations/27217060 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/27217060 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27217060 |
| http://purl.uniprot.org/citations/27217060 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27217060 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z319-mappedCitation-27217060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27217060 |
| http://purl.uniprot.org/uniprot/#_Q07813-mappedCitation-27217060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27217060 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GT35-mappedCitation-27217060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27217060 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GT81-mappedCitation-27217060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27217060 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GTA4-mappedCitation-27217060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27217060 |