| http://purl.uniprot.org/citations/27217487 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27217487 | http://www.w3.org/2000/01/rdf-schema#comment | "The mammalian target of rapamycin complex 1 (mTORC1) regulates several biological processes, although the key downstream mechanisms responsible for these effects are poorly defined. Using mice with deletion of eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2), we determine that this downstream target is a major regulator of glucose homeostasis and β-cell mass, proliferation, and survival by increasing insulin receptor substrate 2 (IRS2) levels and identify a novel feedback mechanism by which mTORC1 signaling increases IRS2 levels. In this feedback loop, we show that 4E-BP2 deletion induces translation of the adaptor protein SH2B1 and promotes the formation of a complex with IRS2 and Janus kinase 2, preventing IRS2 ubiquitination. The changes in IRS2 levels result in increases in cell cycle progression, cell survival, and β-cell mass by increasing Akt signaling and reducing p27 levels. Importantly, 4E-BP2 deletion confers resistance to cytokine treatment in vitro. Our data identify SH2B1 as a major regulator of IRS2 stability, demonstrate a novel feedback mechanism linking mTORC1 signaling with IRS2, and identify 4E-BP2 as a major regulator of proliferation and survival of β-cells."xsd:string |
| http://purl.uniprot.org/citations/27217487 | http://purl.org/dc/terms/identifier | "doi:10.2337/db15-1443"xsd:string |
| http://purl.uniprot.org/citations/27217487 | http://purl.uniprot.org/core/author | "Liu M."xsd:string |
| http://purl.uniprot.org/citations/27217487 | http://purl.uniprot.org/core/author | "Sonenberg N."xsd:string |
| http://purl.uniprot.org/citations/27217487 | http://purl.uniprot.org/core/author | "Yanagiya A."xsd:string |
| http://purl.uniprot.org/citations/27217487 | http://purl.uniprot.org/core/author | "Rui L."xsd:string |
| http://purl.uniprot.org/citations/27217487 | http://purl.uniprot.org/core/author | "Scheys J.O."xsd:string |
| http://purl.uniprot.org/citations/27217487 | http://purl.uniprot.org/core/author | "Bernal-Mizrachi E."xsd:string |
| http://purl.uniprot.org/citations/27217487 | http://purl.uniprot.org/core/author | "Blandino-Rosano M."xsd:string |
| http://purl.uniprot.org/citations/27217487 | http://purl.uniprot.org/core/author | "Jimenez-Palomares M."xsd:string |
| http://purl.uniprot.org/citations/27217487 | http://purl.uniprot.org/core/author | "Bender A.S."xsd:string |
| http://purl.uniprot.org/citations/27217487 | http://purl.uniprot.org/core/author | "Barbaresso R."xsd:string |
| http://purl.uniprot.org/citations/27217487 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27217487 | http://purl.uniprot.org/core/name | "Diabetes"xsd:string |
| http://purl.uniprot.org/citations/27217487 | http://purl.uniprot.org/core/pages | "2235-2248"xsd:string |
| http://purl.uniprot.org/citations/27217487 | http://purl.uniprot.org/core/title | "4E-BP2/SH2B1/IRS2 Are Part of a Novel Feedback Loop That Controls beta-Cell Mass."xsd:string |
| http://purl.uniprot.org/citations/27217487 | http://purl.uniprot.org/core/volume | "65"xsd:string |
| http://purl.uniprot.org/citations/27217487 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27217487 |
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| http://purl.uniprot.org/uniprot/#_Q3UZD4-mappedCitation-27217487 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27217487 |
| http://purl.uniprot.org/uniprot/#_Q3UFP6-mappedCitation-27217487 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27217487 |
| http://purl.uniprot.org/uniprot/#_O88970-mappedCitation-27217487 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27217487 |