| http://purl.uniprot.org/citations/27221474 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27221474 | http://www.w3.org/2000/01/rdf-schema#comment | "Glycogen synthase kinase-3β (GSK-3β), a multifunctional kinase, is an important regulator of cancer cell survival. Apoptosis signal-regulating kinase 1 (ASK1) is also a key factor for controlling several cellular events including the cell cycle, senescence, and apoptosis, in response to reactive oxygen species (ROS). The role of GSK-3β regulating the activity and protein level of ASK1 in the cancer cells remains largely unexplored. In this study, we showed that GSK-3β inhibits ROS-induced hepatocellular carcinoma cell death by suppressing ASK1. We first found that ectopic expression of GSK-3β suppressed hydrogen peroxide (H2O2)-induced cell death in HepG2 cells and knockdown of endogenous GSK-3β expression exhibited opposite effects. Moreover, GSK-3β expression clearly inhibited H2O2-induced phosphorylation of ASK1 in HepG2 cells, in association with a decrease in ASK1 protein level. Further exploration revealed that GSK-3β induced ubiquitination and proteasome-dependent degradation of ASK1 via inhibition of ubiquitin-specific protease USP9X. Our results thus suggest that GSK-3β is a key factor involved in ASK1 activation and ROS-induced cell death."xsd:string |
| http://purl.uniprot.org/citations/27221474 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12032-016-0776-2"xsd:string |
| http://purl.uniprot.org/citations/27221474 | http://purl.uniprot.org/core/author | "Dou Y."xsd:string |
| http://purl.uniprot.org/citations/27221474 | http://purl.uniprot.org/core/author | "Liu L."xsd:string |
| http://purl.uniprot.org/citations/27221474 | http://purl.uniprot.org/core/author | "Zhang N."xsd:string |
| http://purl.uniprot.org/citations/27221474 | http://purl.uniprot.org/core/author | "Song D."xsd:string |
| http://purl.uniprot.org/citations/27221474 | http://purl.uniprot.org/core/author | "Deng H."xsd:string |
| http://purl.uniprot.org/citations/27221474 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27221474 | http://purl.uniprot.org/core/name | "Med Oncol"xsd:string |
| http://purl.uniprot.org/citations/27221474 | http://purl.uniprot.org/core/pages | "60"xsd:string |
| http://purl.uniprot.org/citations/27221474 | http://purl.uniprot.org/core/title | "Glycogen synthase kinase-3beta antagonizes ROS-induced hepatocellular carcinoma cell death through suppression of the apoptosis signal-regulating kinase 1."xsd:string |
| http://purl.uniprot.org/citations/27221474 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/27221474 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27221474 |
| http://purl.uniprot.org/citations/27221474 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27221474 |
| http://purl.uniprot.org/uniprot/#_A0A8V8TMH5-mappedCitation-27221474 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27221474 |
| http://purl.uniprot.org/uniprot/#_A0A3B3ITW1-mappedCitation-27221474 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27221474 |
| http://purl.uniprot.org/uniprot/#_B4DF67-mappedCitation-27221474 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27221474 |
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| http://purl.uniprot.org/uniprot/#_P49841-mappedCitation-27221474 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27221474 |
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| http://purl.uniprot.org/uniprot/#_Q59GL6-mappedCitation-27221474 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27221474 |
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| http://purl.uniprot.org/uniprot/B4DF67 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27221474 |