| http://purl.uniprot.org/citations/27221973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27221973 | http://www.w3.org/2000/01/rdf-schema#comment | "Chromatin Assembly Complex 1 (CAF-1) is a major histone chaperone involved in deposition of histone H3 and H4 into nucleosome. CAF-1 is composed of three subunits; p150, p60 and p48 for human and Cac1, Cac2 and Cac3 for yeast. Despite of its central role in chromatin formation, structural features of the full CAF-1 in complex with histones and other chaperones have not been well characterized. Here, we dissect molecular architecture of yeast CAF-1 (yCAF-1) by cross-linking mass spectrometry (XL-MS) and negative stain single-particle electron microscopy (EM). Our work revealed that Cac1, the largest subunit of yCAF-1, might serve as a major histone binding platform linking Cac2 and Cac3. In addition, EM analysis showed that yCAF-1 adopts a bilobal shape and Cac1 connecting Cac2 and Cac3 to generate a platform for binding histones. This study provides the first structural glimpse of the full CAF-1 complex and a structural framework to understand histone chaperoning processes."xsd:string |
| http://purl.uniprot.org/citations/27221973 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep26702"xsd:string |
| http://purl.uniprot.org/citations/27221973 | http://purl.uniprot.org/core/author | "Aebersold R."xsd:string |
| http://purl.uniprot.org/citations/27221973 | http://purl.uniprot.org/core/author | "Kim D."xsd:string |
| http://purl.uniprot.org/citations/27221973 | http://purl.uniprot.org/core/author | "Chung J."xsd:string |
| http://purl.uniprot.org/citations/27221973 | http://purl.uniprot.org/core/author | "Song J.J."xsd:string |
| http://purl.uniprot.org/citations/27221973 | http://purl.uniprot.org/core/author | "Hebert H."xsd:string |
| http://purl.uniprot.org/citations/27221973 | http://purl.uniprot.org/core/author | "Jung T."xsd:string |
| http://purl.uniprot.org/citations/27221973 | http://purl.uniprot.org/core/author | "Yoon J."xsd:string |
| http://purl.uniprot.org/citations/27221973 | http://purl.uniprot.org/core/author | "Leitner A."xsd:string |
| http://purl.uniprot.org/citations/27221973 | http://purl.uniprot.org/core/author | "Yip C.K."xsd:string |
| http://purl.uniprot.org/citations/27221973 | http://purl.uniprot.org/core/author | "Setiaputra D."xsd:string |
| http://purl.uniprot.org/citations/27221973 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27221973 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/27221973 | http://purl.uniprot.org/core/pages | "26702"xsd:string |
| http://purl.uniprot.org/citations/27221973 | http://purl.uniprot.org/core/title | "Molecular Architecture of Yeast Chromatin Assembly Factor 1."xsd:string |
| http://purl.uniprot.org/citations/27221973 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/27221973 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27221973 |
| http://purl.uniprot.org/citations/27221973 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27221973 |
| http://purl.uniprot.org/uniprot/#_P61830-mappedCitation-27221973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27221973 |
| http://purl.uniprot.org/uniprot/#_P13712-mappedCitation-27221973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27221973 |
| http://purl.uniprot.org/uniprot/#_P02309-mappedCitation-27221973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27221973 |
| http://purl.uniprot.org/uniprot/#_P32447-mappedCitation-27221973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27221973 |
| http://purl.uniprot.org/uniprot/#_Q04199-mappedCitation-27221973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27221973 |