| http://purl.uniprot.org/citations/27225060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27225060 | http://www.w3.org/2000/01/rdf-schema#comment | "Orai channels are required for store-operated Ca(2+) entry (SOCE) in multiple cell types. Septins are a class of GTP-binding proteins that function as diffusion barriers in cells. Here we show that Septin 7 acts as a 'molecular brake' on activation of Orai channels in Drosophila neurons. Lowering Septin 7 levels results in dOrai-mediated Ca(2+) entry and higher cytosolic Ca(2+) in resting neurons. This Ca(2+) entry is independent of depletion of endoplasmic reticulum Ca(2+) stores and Ca(2+) release through the inositol-1,4,5-trisphosphate receptor. Importantly, store-independent Ca(2+) entry through Orai compensates for reduced SOCE in the Drosophila flight circuit. Moreover, overexpression of Septin 7 reduces both SOCE and flight duration, supporting its role as a negative regulator of Orai channel function in vivo. Septin 7 levels in neurons can, therefore, alter neural circuit function by modulating Orai function and Ca(2+) homeostasis."xsd:string |
| http://purl.uniprot.org/citations/27225060 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms11751"xsd:string |
| http://purl.uniprot.org/citations/27225060 | http://purl.uniprot.org/core/author | "Hasan G."xsd:string |
| http://purl.uniprot.org/citations/27225060 | http://purl.uniprot.org/core/author | "Pathak T."xsd:string |
| http://purl.uniprot.org/citations/27225060 | http://purl.uniprot.org/core/author | "Deb B.K."xsd:string |
| http://purl.uniprot.org/citations/27225060 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27225060 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/27225060 | http://purl.uniprot.org/core/pages | "11751"xsd:string |
| http://purl.uniprot.org/citations/27225060 | http://purl.uniprot.org/core/title | "Store-independent modulation of Ca(2+) entry through Orai by Septin 7."xsd:string |
| http://purl.uniprot.org/citations/27225060 | http://purl.uniprot.org/core/volume | "7"xsd:string |
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